{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:50:21Z","timestamp":1790034621969,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T00:00:00Z","timestamp":1561593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Cardinal Health, Inc"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to compare the efficacy of different negative pressure wound therapy (NPWT) devices and NPWT with and without simultaneous irrigation in patients admitted to hospital with moderate and severe foot infections. Ninety patients were randomized in a 12\u2010week prospective, randomized noninferiority trial to compare wound healing in patients with moderate and severe infected foot wounds treated with NPWT after surgery. Inclusion criteria included ABI\u2009&gt;\u20090.5 or toe pressures &gt;30 PVR\/mmHg, &gt;18\u2009years of age and exclusion included active Charcot arthropathy, collagen vascular disease, HIV, and hypercoagulable state. We compared two different traditional devices, NPWT\u2010K (KCI, VAC Ulta) and NPWT\u2010C (Cardinal, PRO), and NPWT\u2010I with saline irrigation (Cardinal, PRO). All patients had therapy delivered at 125\u2009mmHg continuous pressure. In patients who received simultaneous saline irrigation (NPWT\u2010I), the administration rate was 15\u2009ml per hour. The primary outcome was the proportion of healed wounds in 12\u2009weeks. Secondary outcomes included surgical wound closure, number of surgeries, length of stay, and time to wound healing. Continuous data was presented as mean\u2009\u00b1\u2009standard deviation. Analysis of variance was used to compare continuous variables and chi\u2010square to compare dichotomous variables with an alpha of 0.05. There were no differences in outcomes among NPWT\u2010I, NPWT\u2010C, and NPWT\u2010K groups in proportion of healed wounds (63.3%, 50.0%, 46.7% <jats:italic>p<\/jats:italic> = 0.39), surgical wound closure (83.3%, 80.0%, 63.3%, <jats:italic>p<\/jats:italic> = 0.15), number of surgeries (2.0\u2009\u00b1\u20090.49, 2.4\u2009\u00b1\u20090.77, 2.4\u2009\u00b1\u20090.68, <jats:italic>p<\/jats:italic> = 0.06), length of stay (16.3\u2009\u00b1\u200915.7, 14.7\u2009\u00b1\u20097.4, 15.3\u2009\u00b1\u200910.5\u2009days, <jats:italic>p<\/jats:italic> = 0.87), time to wound healing (46.2\u2009\u00b1\u200922.8, 40.9\u2009\u00b1\u200918.8, 45.9\u2009\u00b1\u200928.3\u2009days, <jats:italic>p<\/jats:italic> = 0.78). We did not identify any significant differences in clinical outcomes or adverse events between patients treated with different NPWT devices or NPWT with and without irrigation.<\/jats:p>","DOI":"10.1111\/wrr.12741","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T11:14:54Z","timestamp":1561634094000},"page":"97-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Randomized clinical study to compare negative pressure wound therapy with simultaneous saline irrigation and traditional negative pressure wound therapy for complex foot infections"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4165-8696","authenticated-orcid":false,"given":"Kathryn E.","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"La Fontaine","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Farrar","sequence":"additional","affiliation":[{"name":"Department of Immunology and Molecular Biology University of Texas Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan K.","family":"Oz","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Texas Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5367-9235","authenticated-orcid":false,"given":"Peter A.","family":"Crisologo","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Berriman","sequence":"additional","affiliation":[{"name":"Berriman Consulting  Princeton New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A.","family":"Lavery","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67695-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-2196"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000135330.51408.97"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12456"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12079"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000438060.46290.7a"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","unstructured":"OmarM GathenM LiodakisE SueroE KrettekC ZeckeyC et al.A comparative study of negative pressure wound therapy with and without instillation of saline on wound 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