{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:50:59Z","timestamp":1778626259188,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetic foot ulceration is a common and severe complication of diabetes, causing substantial social, medical, and economic burdens. Treatment of foot ulcers remains challenging, thus requiring increasing awareness and more efficient management. This study investigates the efficacy of ointments, containing as main active ingredient the olive oil extract of the marine isopod <jats:italic>Ceratothoa oestroides<\/jats:italic>, in the treatment of patients with diabetic foot ulcers. Fifty\u2010two patients were allocated into four treatment groups either receiving therapy with an ointment containing extract of <jats:italic>C. oestroides<\/jats:italic> or extract of <jats:italic>C. oestroides<\/jats:italic> and eosin or extract of <jats:italic>C. oestroides<\/jats:italic> and cefaclor or no treatment. Patients were monitored for a period of 135\u2009days by evaluation of transepidermal water loss, skin hydration, planimetry, photo\u2010documentation, and clinical condition. Treatment with the extract of <jats:italic>C. oestroides<\/jats:italic> demonstrated significant healing properties that became evident after 45\u2009days of treatment and resulted in complete ulcer healing in 61% of the patients. A significant improvement in transepidermal water loss (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), skin hydration levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and wound area (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) was observed in all patients. Similar efficacy was demonstrated for the combination of <jats:italic>C. oestroides<\/jats:italic> extract with eosin treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). On the contrary, the combination of <jats:italic>C. oestroides<\/jats:italic> extract with cefaclor antibiotic agent completely inhibited the healing properties of the isopod extract and did not improve water loss, skin hydration, or wound area. An important factor for <jats:italic>C. oestroides<\/jats:italic> extract healing properties is its selective activity against Gram negative bacteria. Ointments containing <jats:italic>C. oestroides<\/jats:italic> extract alone or combined with the antimicrobial agent eosin emerges as an effective regimen for the treatment of diabetic foot ulcers.<\/jats:p>","DOI":"10.1111\/wrr.12771","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T22:32:03Z","timestamp":1571265123000},"page":"234-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ointments containing <i>Ceratothoa oestroides<\/i> extract: Evaluation of their healing potential in the treatment of diabetic foot ulcers"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5031-8629","authenticated-orcid":false,"given":"Evangelia","family":"Meimeti","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Technology, Panepistimiopolis Zografou National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Tentolouris","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens, 1st Department of Propaedeutic Internal Medicine Medical School, Laiko General Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Manes","sequence":"additional","affiliation":[{"name":"Diabetic Foot Department General Hospital of Thessaloniki Papageorgiou  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chariclia","family":"Loupa","sequence":"additional","affiliation":[{"name":"Demetrios Voyatzoglou Diabetic Foot Clinic A. Fleming Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xeni","family":"Provatopoulou","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Technology, Panepistimiopolis Zografou National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Mostratos","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Technology, Panepistimiopolis Zografou National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Vitsos","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Technology, Panepistimiopolis Zografou National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassilios","family":"Roussis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Section of Pharmacognosy and Chemistry of Natural Products, Panepistimiopolis Zografou National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonidas","family":"Tzouvelekis","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens, Department of Microbiology Medical School, University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivi","family":"Miriagou","sequence":"additional","affiliation":[{"name":"Laboratory of Bacteriology Hellenic Pasteur Institute  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michail","family":"Rallis","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Pharmaceutical Technology, Panepistimiopolis Zografou National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1231932"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-003-0010-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04415.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2017.1333596"},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: a health technology assessment","volume":"17","author":"Health Quality Ontario","year":"2017","journal-title":"Ont Health Technol Assess Ser"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2017.26.Sup2.S4"},{"key":"e_1_2_7_8_1","first-page":"239","article-title":"Treating diabetic foot ulcers using the system applying negative pressure","volume":"23","author":"Meimeti E","year":"2010","journal-title":"Hellenic Diabetolog Chronicle"},{"key":"e_1_2_7_9_1","unstructured":"LoupaC MeimetiE DonouA VoyatzoglouE BakasI VoyatzoglouD. 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