{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T01:39:07Z","timestamp":1774489147788,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1132444"],"award-info":[{"award-number":["APP1132444"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic venous leg ulcers are challenging to heal and often recur. This has a significant impact on older individual health and is a financial burden on health care resources. This study aimed to identify factors associated with the healing of venous leg ulcers via secondary examination of data from a previously published prospective randomized controlled trial of elastic and inelastic compression systems. The data from the 45 patients who finished the trial was reanalyzed for a hypothesis generating study. Larger ulcers, higher exudate levels, larger calf circumferences, and longer ulcer duration at baseline were associated with lack of healing at 12\u2009weeks. There was some evidence that NSAID use was associated with an increased likelihood of nonhealing (unadjusted OR for healing, 0.13, 95% CI (0.02, 0.70)). There was no evidence that other variables, including gender and BMI, were associated with healing. The key risk factors for wound healing are largely wound based or inherent to wound development, as these were found to be the factors with the strongest associations in the analysis. Future research should address how and why these factors are associated with wound healing over a longer time frame and explore how NSAIDs may affect wound healing outcomes.<\/jats:p>","DOI":"10.1111\/wrr.12773","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T05:33:10Z","timestamp":1571808790000},"page":"211-218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Associations between patient, treatment, or wound\u2010level factors and venous leg ulcer healing: Wound characteristics are the key factors in determining healing outcomes"],"prefix":"10.1111","volume":"28","author":[{"given":"Carolina D.","family":"Weller","sequence":"first","affiliation":[{"name":"Monash Nursing and Midwifery  Level 5 Alfred Centre, 99 Commercial Road, Melbourne Victoria 3004 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5843-3533","authenticated-orcid":false,"given":"Ayoub","family":"Bouguettaya","sequence":"additional","affiliation":[{"name":"Monash Nursing and Midwifery  Level 5 Alfred Centre, 99 Commercial Road, Melbourne Victoria 3004 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6615-6874","authenticated-orcid":false,"given":"Victoria","family":"Team","sequence":"additional","affiliation":[{"name":"Monash Nursing and Midwifery  Level 5 Alfred Centre, 99 Commercial Road, Melbourne Victoria 3004 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Flegg","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics University of Melbourne  Level 3, Old Geology South, Parkville Victoria 3010 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Kasza","sequence":"additional","affiliation":[{"name":"Monash School of Public Health and Preventative Medicine Monash University  553 St Kilda Road, Melbourne Victoria 3004 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chathranee","family":"Jayathilake","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics University of Melbourne  Level 3, Old Geology South, Parkville Victoria 3010 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"Venous leg ulcers","volume":"2016","author":"Nelson EA","year":"2016","journal-title":"BMJ Clin Evid"},{"key":"e_1_2_8_3_1","first-page":"331","article-title":"Venous leg ulcer management in general practice\u2014practice nurses and evidence based guidelines","volume":"41","author":"Weller C","year":"2012","journal-title":"Aust Fam Physician"},{"key":"e_1_2_8_4_1","first-page":"84","article-title":"Solutions to the chronic wounds problem in Australia: a call to action","volume":"26","author":"Pacella RE","year":"2018","journal-title":"Wound Practice and Research"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2016.25.Sup6.S1"},{"key":"e_1_2_8_6_1","unstructured":"Australian Bureau of Statistics (ABS). 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