{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T19:44:35Z","timestamp":1776800675368,"version":"3.51.2"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitiligo, a common skin disorder, is characterized by the loss of functional melanocytes resulting in the depigmentation of skin. Previous studies have demonstrated molecular and architectural alterations in the epidermal keratinocytes upon loss of melanocytes. The physiological implications of these \u201caltered\u201d keratinocytes are yet not known. We investigated the wound healing efficiency of lesional vs nonlesional skin in 12 subjects with stable nonsegmental vitiligo using histological and ultrastructural evaluation of partial\u2010thickness wounds. The wounds were examined 12\u2009days postinjury, coinciding with the reepithelialization phase of healing marked primarily by keratinocyte migration and proliferation. This study demonstrated a significant difference in the reepithelialization potential between the lesional and nonlesional skin. While all 12 nonlesional wounds demonstrated considerable neoepidermis formation on the 12th day post wound, only four of the corresponding lesional samples showed comparable reepithelialization; the rest remaining in the inflammatory phase. Ultrastructural studies using transmission electron microscopy as well as immunohistochemical staining revealed a reduced number of desmosomes, shorter keratin tonofilaments and an increase in myofibroblast population in the dermis of lesional reepithelialized tissue compared to the nonlesional reepithelialized samples. This study implicates gross functional perturbations in the lesional skin during physiological wound healing in vitiligo, suggesting that the breakdown of keratinocyte\u2010melanocyte network results in delayed wound repair kinetics in the lesional skin when compared to patient\u2010matched nonlesional skin.<\/jats:p>","DOI":"10.1111\/wrr.12798","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T11:27:06Z","timestamp":1580470026000},"page":"307-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lesional skin in vitiligo exhibits delayed in vivo reepithelialization compared to the nonlesional skin"],"prefix":"10.1111","volume":"28","author":[{"given":"Aayush","family":"Gupta","sequence":"first","affiliation":[{"name":"Dr. D. Y. Patil Medical College Hospital and Research Centre  Pune Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aparna","family":"Chauhan","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology (CSIR\u2010IGIB)  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anshu","family":"Priya","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology (CSIR\u2010IGIB)  New Delhi India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhanu","family":"Mantri","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology (CSIR\u2010IGIB)  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenakshi","family":"Wadhokar","sequence":"additional","affiliation":[{"name":"Dr. D. Y. Patil Medical College Hospital and Research Centre  Pune Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalyan","family":"Dalave","sequence":"additional","affiliation":[{"name":"Dr. D. Y. Patil Medical College Hospital and Research Centre  Pune Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhavika","family":"Shah","sequence":"additional","affiliation":[{"name":"Dr. D. Y. Patil Medical College Hospital and Research Centre  Pune Maharashtra India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh S.","family":"Gokhale","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology (CSIR\u2010IGIB)  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vineeta V.","family":"Batra","sequence":"additional","affiliation":[{"name":"Govind Ballabh Pant Institute of Postgraduate Medical Education and Research  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1388-9489","authenticated-orcid":false,"given":"Archana","family":"Singh","sequence":"additional","affiliation":[{"name":"CSIR\u2010Institute of Genomics and Integrative Biology (CSIR\u2010IGIB)  New Delhi India"},{"name":"Academy of Scientific and Innovative Research (AcSIR)  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00178.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2007.00385.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000171"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2340\/0001555576429432","article-title":"Photoprotection in vitiligo and normal skin. A quantitative assessment of the role of stratum corneum, viable epidermis and pigmentation","volume":"76","author":"Gniadecka M","year":"1996","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10253-w"},{"issue":"407","key":"e_1_2_8_7_1","first-page":"10","article-title":"Wound healing and the role of fibroblasts","volume":"22","author":"Bainbridge P","year":"2007","journal-title":"J Wound Care"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700786"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009337"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008383"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare2040445"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12500086"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1983.tb00328.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12325"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12344"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12688"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00430822"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-11-0720"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.241"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.201"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.06.033"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2012.1117"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.08.038"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2008.07.009"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.11.034"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05389.x"},{"key":"e_1_2_8_27_1","first-page":"609","article-title":"The contribution of melanocytes to pathological scar formation during wound healing","volume":"6","author":"Gao FL","year":"2013","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.010371"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.1997.17"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197402000-00004"},{"key":"e_1_2_8_31_1","doi-asserted-by":"crossref","unstructured":"JABrown BSmoller. Special Stains in Dermatopathology. Connection 2010.","DOI":"10.1007\/978-1-4419-0024-1_3"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12798","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12798","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.12798","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T06:23:52Z","timestamp":1694067832000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/wrr.12798"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12798","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,18]]},"assertion":[{"value":"2019-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}