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Given the high rate of depressive symptoms experienced by patients with chronic wounds, further studies are needed to investigate the potentially linked pathophysiological changes in wounds and depression in order to improve patient care. The English literature on wound healing, inflammatory and microbial changes in chronic wounds and depression, and antiinflammatory and probiotic therapy was reviewed on PubMed. Chronic wound conditions and depression were demonstrated to share common pathologic features of dysregulated inflammation and altered microbiome, indicating a possible relationship. Furthermore, alternative treatment strategies such as immune\u2010targeted and probiotic therapy showed promising potential by addressing both pathophysiological pathways. However, many existing studies are limited to a small study population, a cross\u2010sectional design that does not establish temporality, or a wide range of confounding variables in the context of a highly complex and multifactorial disease process. Therefore, additional preclinical studies in suitable wound models, as well as larger clinical cohort studies and trials are necessary to elucidate the relationship between wound microbiome, healing, and depression, and ultimately guide the most effective therapeutic and management plan for chronic wound patients.<\/jats:p>","DOI":"10.1111\/wrr.12800","type":"journal-article","created":{"date-parts":[[2020,2,8]],"date-time":"2020-02-08T00:16:16Z","timestamp":1581120976000},"page":"282-292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Microbiome\u2010skin\u2010brain axis: A novel paradigm for cutaneous wounds"],"prefix":"10.1111","volume":"28","author":[{"given":"Yasmin","family":"Hadian","sequence":"first","affiliation":[{"name":"Department of Dermatology, School of Medicine University of California  Davis California"},{"name":"Dermatology Section VA Northern California Health Care System  Mather 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