{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:09:24Z","timestamp":1791126564571,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T00:00:00Z","timestamp":1588550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nearly 70% of older adults in the U.S. report using \u22651 dietary supplements (DSs) daily. While DSs may have health benefits, there is risk for toxicity or harmful drug\u2010supplement interactions if not taken correctly. Older adults with chronic wounds who use DSs are at increased risk of adverse drug\u2010supplement interactions because they usually have comorbidities requiring polypharmacy management. However, no studies have evaluated DS use in this population. The aim of this retrospective pilot study was to describe DS use by a sample of older adults (n = 40) with chronic venous leg ulcers (CVLUs) who participated in a clinical trial testing the effects of fish oil supplementation on wound healing. At baseline, study personnel assisted all participants in completing an electronic questionnaire about DS use. Descriptive statistics were used to characterize the data. Twenty\u2010five of the 40 participants (62.5%) reported taking \u22651 DS daily. On average, DS users were 65.16\u2009years (<jats:italic>SD<\/jats:italic> = 8.51) and the majority were men (64.0%), white (68.0%), and had at least some college education (72.0%). Fifteen (60.0%) reported taking 1\u20102 DSs\/day, and 10 (40.0%) reported taking \u22653\/day. The most frequently reported DSs used were multivitamin\/mineral complex (60.0%), vitamin D (36.0%), vitamin B complex (28.0%) and calcium (28.0%). Reasons for using DSs were to maintain or improve health (44.0%), improve bone density (12%), and boost the immune system (12%). Supplement users reported consuming an average of 9.12 (<jats:italic>SD<\/jats:italic> = 6.46) prescription drugs daily and 21 (84.0%) reported \u22653 chronic health conditions. In summary, DS use in this sample of chronic wound patients was high. Moreover, DS users reported using multiple prescription drugs (2\u201023\/day) concomitantly with DSs. While older adults with CVLUs may benefit from targeted DS therapy, monitoring their DS use to reduce risk for adverse drug\u2010supplement interactions is best practice.<\/jats:p>","DOI":"10.1111\/wrr.12821","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T00:10:18Z","timestamp":1587514218000},"page":"561-572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dietary supplement use by older adults with chronic venous leg ulcers: A retrospective, descriptive study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3089-4928","authenticated-orcid":false,"given":"Jodi C.","family":"McDaniel","sequence":"first","affiliation":[{"name":"College of Nursing, The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Dietary Supplement Health and Education Act of 1994. 1994; S. 784 (103rd)."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1M238"},{"key":"e_1_2_7_4_1","unstructured":"US Food and Drug Administration. FDA 101: dietary supplements.https:\/\/www.fda.gov\/consumers\/consumer-updates\/fda-101-dietary-supplements. Accessed October 25 2019."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.117.255984"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.8581"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2007.05.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2014.0530"},{"key":"e_1_2_7_9_1","first-page":"207","article-title":"Assessment and management of nutrition in older people and its importance to health","volume":"5","author":"Ahmed T","year":"2010","journal-title":"Clin Interv Aging"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/bega.2001.0246"},{"key":"e_1_2_7_11_1","unstructured":"Institute of Medicine (US). Subcommittee on Interpretation and Uses of Dietary Reference Intakes Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. 2000. [bookaccession]."},{"key":"e_1_2_7_12_1","volume-title":"Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride","author":"Institute of Medicine, National Academy of Sciences","year":"1997"},{"key":"e_1_2_7_13_1","volume-title":"Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenumum, Nickel, Silicon, Vanadium, and Zinc","author":"Institute of Medicine, National Academy of Sciences","year":"2001"},{"key":"e_1_2_7_14_1","volume-title":"Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids","author":"Institute of Medicine, National Academy of Sciences","year":"2000"},{"key":"e_1_2_7_15_1","volume-title":"Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline","author":"Institute of Medicine, National Academy of Sciences","year":"1998"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(01)00026-8"},{"key":"e_1_2_7_17_1","unstructured":"Natural Medicines Comprehensive Database. Vitamin A.https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food -herbs-supplements\/professional.aspx?productid=964#interactionsWithDrugs. Accessed October 20 2019."},{"key":"e_1_2_7_18_1","unstructured":"Natural Medicines Comprehensive Database. Vitamin B6.https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food -herbs-supplements\/professional.aspx?productid=934#interactionsWithDrugs. Accessed October 20 2019."},{"key":"e_1_2_7_19_1","unstructured":"Natural medicines Comprehensive Database. Vitamin D.https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food -herbs-supplements\/professional.aspx?productid=929#interactionsWithDrugs. Accessed October 20 2019."},{"key":"e_1_2_7_20_1","unstructured":"Natural Medicines Comprehensive Database. Vitamin E.https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food -herbs-supplements\/professional.aspx?productid=954#interactionsWithDrugs. Accessed October 20 2019."},{"key":"e_1_2_7_21_1","unstructured":"Natural Medicines Comprehensive Database. Vitamin K.https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food -herbs-supplements\/professional.aspx?productid=983#interactionsWithDrugs. Accessed October 20 2019."},{"key":"e_1_2_7_22_1","unstructured":"Natural Medicines Comprehensive Database. Calcium.https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food -herbs-supplements\/professional.aspx?productid=781#interactionsWithDrugs. Accessed October 20 2019."},{"key":"e_1_2_7_23_1","unstructured":"Natural Medicines Comprehensive Database. Iron.https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food -herbs-supplements\/professional.aspx?productid=912#interactionsWithDrugs. Accessed October 20 2019."},{"key":"e_1_2_7_24_1","unstructured":"Natural Medicines Comprehensive Database. Zinc.https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food -herbs-supplements\/professional.aspx?productid=982#interactionsWithDrugs. Accessed October 20 2019."},{"key":"e_1_2_7_25_1","unstructured":"Natural Medicines Comprehensive Database. Ginkgo.https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food -herbs-supplements\/professional.aspx?productid=333#interactionsWithDrugs. Accessed October 20 2019."},{"key":"e_1_2_7_26_1","unstructured":"Natural Medicines Comprehensive Database. Goldenseal.https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food -herbs-supplements\/professional.aspx?productid=943#interactionsWithDrugs. Accessed October 20 2019."},{"key":"e_1_2_7_27_1","unstructured":"Natural Medicines Comprehensive Database. St. John's worthttps:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food -herbs-supplements\/professional.aspx?productid=329#interactionsWithDrugs. Accessed October 20 2019."},{"key":"e_1_2_7_28_1","unstructured":"Natural Medicines Comprehensive Database. Niacin.https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food -herbs-supplements\/professional.aspx?productid=924. Accessed October 20 2019."},{"key":"e_1_2_7_29_1","unstructured":"Natural Medicines Comprehensive Database. Magnesium.https:\/\/naturalmedicines.therapeuticresearch.com\/databases\/food -herbs-supplements\/professional.aspx?productid=998#interactionsWithDrugs. Accessed October 20 2019."},{"issue":"343","key":"e_1_2_7_30_1","first-page":"1","article-title":"Complementary and alternative medicine use among adults: United States, 2002","author":"Barnes PM","year":"2004","journal-title":"Adv Data."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2018-0515"},{"key":"e_1_2_7_32_1","unstructured":"MedMarketDL.Wound prevalence and wound management 2012\u20132020. Report #S190 and Report #251."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.9.927"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2009.02329.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14887"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200926050-00006"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-016-0742-x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2008.0290"},{"key":"e_1_2_7_39_1","volume-title":"Dietary Reference Intakes: The Essential Guide to Nutrient Requirements","author":"Institute of Medicine","year":"2006"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-12-201312170-00729"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0115426505020002281"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.020289"},{"key":"e_1_2_7_43_1","volume-title":"Dietary Reference Intakes: The Essential Guide to Nutrient Requirements","author":"Otten","year":"2006"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(98)00171-3"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-0690(02)00059-9"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.03016.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-009-0214-7"},{"key":"e_1_2_7_48_1","unstructured":"The Natural Medicine Comprehensive Database.https:\/\/naturalmedicines.therapeuticresearch.com\/about-us.aspx. Accessed October 20 2019."}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fwrr.12821","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12821","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.12821","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T15:34:18Z","timestamp":1693582458000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,4]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/wrr.12821"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12821","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,4]]},"assertion":[{"value":"2019-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}