{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:16:51Z","timestamp":1781705811328,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["3 U24 DK076169\u201008S4"],"award-info":[{"award-number":["3 U24 DK076169\u201008S4"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study is to evaluate serum biomarkers to monitor high\u2010risk patients for reinfection of bone. Thirty\u2010five patients were prospectively enrolled with moderate to severe diabetic foot infections with suspicion of osteomyelitis. Bone samples were obtained for culture and histology. Clinical characteristics and outcomes of patients were compared using <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> square test. Biomarkers (white blood cell count, erythrocyte sedimentation rate, c\u2010reactive protein, procalcitonin, interleukin\u20106, interleukin\u20108, and monocyte chemoattractant protein 1) were assessed at baseline, 3, and 6\u2009weeks after treatment initiation and evaluated for correlation with reinfection of bone. After 6\u2009weeks of antibiotic treatment, ESR at 73.5\u2009mm\/h (sensitivity 62.5%, specificity 100%, area under the receiver operating characteristic (AUROC) 0.7839, 95% CI 0.54\u20101.00, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) and IL\u20108 at 15.09\u2009mg\/dL (sensitivity 42.9%, specificity 92.0% AUROC 0.6286, 95% CI 0.36\u20100.90, <jats:italic>P<\/jats:italic> = .0496) were associated with reinfection of bone. An increase in IL\u20108 from week 0 to 6 &gt;0.95\u2009mg\/dL was associated with reinfection (sensitivity 71%, specificity 72% AUROC 0.7057, 95% CI 0.49\u20100.92, <jats:italic>P<\/jats:italic> = .04). An ESR change from week 0\u20106 of \u221216.5% (sensitivity 71.4%, specificity 86.4% AUROC 0.7403, 95% CI 0.48\u20101.00, <jats:italic>P<\/jats:italic> = .02), CRP (\u2010)74.4% (sensitivity 66.7%, specificity 91.3% AUROC 0.7174, 95% CI 0.40\u20101.00, <jats:italic>P<\/jats:italic> = .04), IL\u20106 (\u2010)49.9% (sensitivity 71.4%, specificity 76% AUROC 0.7371, 95% CI 0.47\u20101.00, <jats:italic>P<\/jats:italic> = .04), and IL\u20108 29% (sensitivity 85.7%, specificity 56.0% AUROC of 0.7343, 95% CI 0.54\u20100.93, <jats:italic>P<\/jats:italic> = .048) were associated with increased risk of reinfection. Pilot data suggest that serum biomarkers (ESR, IL8 and IL6, MCP\u20101) may be correlated with developing osteomyelitis and could be used to monitor high\u2010risk patients for reinfection.<\/jats:p>","DOI":"10.1111\/wrr.12836","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T22:28:27Z","timestamp":1595456907000},"page":"617-622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The infected diabetic foot: Can serum biomarkers predict osteomyelitis after hospital discharge for diabetic foot infections?"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5367-9235","authenticated-orcid":false,"given":"Peter Andrew","family":"Crisologo","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4165-8696","authenticated-orcid":false,"given":"Kathryn E.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junho","family":"Ahn","sequence":"additional","affiliation":[{"name":"The University of Texas Southwestern Medical School  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Farrar","sequence":"additional","affiliation":[{"name":"Department of Immunology and Molecular Biology University of Texas Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Van Asten","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"La Fontaine","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A.","family":"Lavery","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0491-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12146"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/511036"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1071100716664364"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis346"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12574"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2699"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.7547\/1030002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-010-0128-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12545"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1514"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13935"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12433"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4417-x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399811666150713104401"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/230949901602400118"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2005.07.006"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e318163f9ee"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3550-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734613486152"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1744"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.7547\/1030024"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1131-8"},{"issue":"8","key":"e_1_2_7_25_1","first-page":"205","article-title":"The 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