{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:55:47Z","timestamp":1790146547268,"version":"4.0.1"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hypertrophic scars are still a major burden for numerous patients, especially after burns. Many treatment options are available; however, no evidence\u2010based treatment protocol is available with recommendations mostly emerging from experience or lower quality studies. This review serves to discuss the currently available literature. A systematic review was performed and the databases\n                    <jats:italic>PubMed<\/jats:italic>\n                    and\n                    <jats:italic>Web of Science<\/jats:italic>\n                    were searched for suitable publications. Only original articles in English that dealt with the treatment of hypertrophic scars in living humans were analyzed. Further, studies with a level of evidence lower than 1 as defined by the American Society of Plastic Surgeons were excluded. After duplicate exclusion, 1638 studies were screened. A qualitative assessment yielded 163 articles eligible for evidence grading. Finally nine studies were included. Four of them used intralesional injections, four topical therapeutics and one assessed the efficacy of CO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010laser. Intralesional triamcinolone\u2009+\u2009fluorouracil injections, and topical pressure and\/or silicone therapy revealed significant improvements in terms of scar height, pliability, and pigmentation. This systematic review showed that still few high\u2010quality studies exist to evaluate therapeutic means and their mechanisms for hypertrophic scars. Among these, most of them assessed the efficacy of intralesional triamcinolone injections with the same treatment protocol. Intralesional injection appears to be the best option for hypertrophic scar treatment. Future studies should focus on a possible optimization of infiltrative therapies, consistent end\u2010point evaluations, adequate follow\u2010up periods, and possibly intraindividual treatments.\n                  <\/jats:p>","DOI":"10.1111\/wrr.12839","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T08:29:55Z","timestamp":1591518595000},"page":"656-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Evidence\u2010based therapy in hypertrophic scars: An update of a systematic review"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6621-4891","authenticated-orcid":false,"given":"Sebastian P.","family":"Nischwitz","sequence":"first","affiliation":[{"name":"COREMED \u2013 Cooperative Centre for Regenerative Medicine, JOANNEUM RESEARCH Forschungsgesellschaft mbH  Graz Austria"},{"name":"Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Rauch","sequence":"additional","affiliation":[{"name":"KAGes, The Healthcare Company of Styria  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9106-0831","authenticated-orcid":false,"given":"Hanna","family":"Luze","sequence":"additional","affiliation":[{"name":"COREMED \u2013 Cooperative Centre for Regenerative Medicine, JOANNEUM RESEARCH Forschungsgesellschaft mbH  Graz Austria"},{"name":"Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Hofmann","sequence":"additional","affiliation":[{"name":"COREMED \u2013 Cooperative Centre for Regenerative Medicine, JOANNEUM RESEARCH Forschungsgesellschaft mbH  Graz Austria"},{"name":"Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Draschl","sequence":"additional","affiliation":[{"name":"Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Kotzbeck","sequence":"additional","affiliation":[{"name":"COREMED \u2013 Cooperative Centre for Regenerative Medicine, JOANNEUM RESEARCH Forschungsgesellschaft mbH  Graz Austria"},{"name":"Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars\u2010Peter","family":"Kamolz","sequence":"additional","affiliation":[{"name":"COREMED \u2013 Cooperative Centre for Regenerative Medicine, JOANNEUM RESEARCH Forschungsgesellschaft mbH  Graz Austria"},{"name":"Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2015.11.015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e3182374452"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2014.02.011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18030606"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12739"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032712-095937"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.08.009"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2009.00638.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2009.00153"},{"issue":"83","key":"e_1_2_9_11_1","article-title":"Current 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PROSPERO \u2010 International prospective register of systematic reviews 2019.https:\/\/www.crd.york.ac.uk\/prospero\/Accessed September 16 2019."},{"key":"e_1_2_9_40_1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1610-0387.2012.08012.x","article-title":"German S2k guidelines for the therapy of pathological scars (hypertrophic scars and keloids)","volume":"10","author":"Nast A","year":"2012","journal-title":"J Der Dtsch Dermatologischen Gesellschaft"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2018.08.011"},{"key":"e_1_2_9_42_1","first-page":"1003","article-title":"Intralesional triamcinolone alone and in combination with 5\u2010fluorouracil for the treatment of keloid and hypertrophic scars","volume":"64","author":"Khan MA","year":"2014","journal-title":"J Pak Med Assoc"},{"key":"e_1_2_9_43_1","first-page":"578","article-title":"Comparison between the efficacy of intra\u2010lesional triamcenolone and combination of triamcinolone 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