{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:39Z","timestamp":1787016099850,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A prospective, single arm feasibility study was conducted to evaluate healing outcomes of DFUs treated with autologous skin cell suspension (ASCS) in combination with standard therapy. Wounds up to 100\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    in size that failed to heal with conventional therapy were included and wound healing, pain, exudate scores, Quality of Life, satisfaction scores, and safety outcomes were evaluated over a period of 26\u2009weeks. Sixteen subjects were enrolled having a mean DFU duration of 60.4\u2009weeks. All ulcers in this study had a positive healing trajectory, with a mean reepithelialization of 84.9% and 12.2 cm\n                    <jats:sup>2<\/jats:sup>\n                    reduction in ulcer area. For ulcers that did not acquire a soft tissue infection post\u2010treatment, all either healed or achieved \u226595% reepithelialization including some with exposed tendon. Improvements were observed in all aspects of the health\u2010related Quality of Life questionnaire and subjects and clinicians were highly satisfied across all postoperative visits. This preliminary study suggests ASCS is a well\u2010tolerated and promising therapy for the treatment of DFUs as all ulcers evaluated experienced positive healing results regardless of size, depth, and wound duration. Future studies are warranted to investigate ASCS compared to standard of care for all diabetic foot ulcers, inclusive of the evaluation of treatment algorithms and combination products.\n                  <\/jats:p>","DOI":"10.1111\/wrr.12844","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T01:14:42Z","timestamp":1595207682000},"page":"719-727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A pilot feasibility study of non\u2010cultured autologous skin cell suspension for healing diabetic foot ulcers"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5377-8671","authenticated-orcid":false,"given":"S. Tawqeer","family":"Rashid","sequence":"first","affiliation":[{"name":"Manchester Royal Infirmary &amp; University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Cavale","sequence":"additional","affiliation":[{"name":"Kings College Hospital London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank L.","family":"Bowling","sequence":"additional","affiliation":[{"name":"Manchester Royal Infirmary &amp; University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.13.5.513"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(98)00181-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.2.217"},{"key":"e_1_2_7_5_1","unstructured":"International Best Practice Guidelines: Wound Management in Diabetic Foot Ulcers. Wounds International;2013."},{"key":"e_1_2_7_6_1","unstructured":"Diabetes UK Position Statement: Putting feet first: Diabetes UK position on preventing amputations and improving foot care for people with diabetes;2014."},{"key":"e_1_2_7_7_1","unstructured":"Nice clinical guidance 10. Type 2 Diabetes Foot Problems: Prevention and Management of Foot Problems;2014."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-9021"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.7.1591"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2249"},{"key":"e_1_2_7_11_1","first-page":"e009283","article-title":"Health economic burden that different wound types impose on the UK's National Health Service","volume":"5","author":"Guest J","year":"2015","journal-title":"Br Med J Open"},{"issue":"8","key":"e_1_2_7_12_1","first-page":"CD006810","article-title":"Granulocyte\u2010colony stimulating factors as adjunctive therapy for diabetic foot infections","author":"Cruciani M","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"e_1_2_7_13_1","first-page":"CD010318","article-title":"Negative pressure wound therapy for treating foot wounds in people with diabetes 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