{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:09:36Z","timestamp":1747188576583,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Advances in patient care for pressure injuries (PIs) have reduced the prevalence of PIs in Japan, although not in recent years. Several single\u2010nucleotide polymorphisms (SNPs) have been identified in genes potentially associated with PIs. However, individual variance among PI risks require targeted investigations that may lead to the identification of PI susceptibilities or preventive care options that directly influence PI development pathways. This cross\u2010sectional study examined the association between PIs and SNPs in genes related to tissue tolerance in patients in a long\u2010term care hospital in Japan. A total of 178 participants (130 control, 20 with superficial PI history, and 28 with deep PI history) were enrolled in this study of eight SNPs in <jats:italic>hypoxia inducible factor 1 subunit alpha<\/jats:italic> (<jats:italic>HIF1A<\/jats:italic>), <jats:italic>vascular endothelial growth factor C<\/jats:italic> (<jats:italic>VEGFC<\/jats:italic>), <jats:italic>heat shock protein 90 alpha family class A member 1<\/jats:italic> (<jats:italic>HSP90AA1<\/jats:italic>), <jats:italic>myostatin<\/jats:italic> (<jats:italic>MSTN<\/jats:italic>), and <jats:italic>vitamin D receptor<\/jats:italic> (<jats:italic>VDR<\/jats:italic>). The primary outcome was a history of superficial and deep PIs in the last 6 months. SNPs were examined by real\u2010time polymerase chain reaction, followed by multivariate logistic regression analyses of the associations between the SNPs and PI history. The results showed a significant association between <jats:italic>VEGFC<\/jats:italic> rs1485766 and the history of superficial PIs (odds ratio\u00a0=\u00a02.95; 95% confidence interval\u00a0=\u00a01.07\u20138.11; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). Stratified analysis using the Braden Scale (\u226414) indicated a significant association between <jats:italic>HIF1A<\/jats:italic> rs11549465 and deep PIs (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). Our study demonstrated that <jats:italic>VEGFC<\/jats:italic> rs1485766 and <jats:italic>HIF1A<\/jats:italic> rs11549465 were associated with superficial and deep PI susceptibilities, respectively.<\/jats:p>","DOI":"10.1111\/wrr.12912","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T18:14:56Z","timestamp":1617646496000},"page":"741-751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polymorphism analysis of candidate risk genes for pressure injuries in older Japanese patients: A cross\u2010sectional study at a long\u2010term care hospital"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5446-7242","authenticated-orcid":false,"given":"Toshihiro","family":"Tsukatani","sequence":"first","affiliation":[{"name":"Department of Gerontological Nursing\/Wound Care Management, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-7290","authenticated-orcid":false,"given":"Takeo","family":"Minematsu","sequence":"additional","affiliation":[{"name":"Department of Skincare Science, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Division of Care Innovation, Global Nursing Research Center, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misako","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Skincare Science, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Tamai","sequence":"additional","affiliation":[{"name":"Division of Care Innovation, Global Nursing Research Center, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Imaging Nursing Science, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9650-2464","authenticated-orcid":false,"given":"Gojiro","family":"Nakagami","sequence":"additional","affiliation":[{"name":"Department of Gerontological Nursing\/Wound Care Management, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Division of Care Innovation, Global Nursing Research Center, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Sugama","sequence":"additional","affiliation":[{"name":"Advanced Health Care Science Research Unit, Innovative Integrated Bio\u2010Research Core, Institute for Frontier Science Initiative Kanazawa University  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Takada","sequence":"additional","affiliation":[{"name":"The Nursing Department Sengi Hospital  Kanazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Sanada","sequence":"additional","affiliation":[{"name":"Department of Gerontological Nursing\/Wound Care Management, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Division of Care Innovation, Global Nursing Research Center, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,5]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"European Pressure Ulcer Advisory Panel National Pressure Injury Advisory Panel and Pan Pacific Pressure Injury Alliance. 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