{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:43:58Z","timestamp":1790685838800,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic venous ulcers affect 1% of the adult population and are associated with a marked reduction in quality of life, especially if healing is prolonged. Several matrix metalloproteinases (MMPs) appear to be involved in the pathophysiology of chronic venous ulcer healing, but their exact role is still unclear. Cyclooxygenase\u20102 (COX\u20102) is an important enzyme in prostanoid synthesis, induced during inflammation in chronic venous ulcer. The first aim of our study was to compare the expression of MMP\u20101, MMP\u20102, and COX\u20102 in wound tissue to that in normal skin. The second aim was to observe the expression of the above factors in 29 chronic venous ulcers in 22 patients at the beginning and 4\u2009weeks later in relation to healing rates and final healing outcome after 24\u2009weeks. The enrolled population was divided into two groups, healed and non\u2010healed wounds after 24\u2009weeks. The intensity of expression of MMP\u20101, MMP\u20102 and COX\u20102 was assessed for each ulcer in paired wound biopsy samples and wound size measurements using laser triangulation at the beginning and after 4\u2009weeks of observation. Initial healing rates in the first 4\u2009weeks were calculated and proved to be an important predictive factor of healing in 24\u2009weeks. Decreases in MMP\u20101 and MMP\u20102 after 4\u2009weeks of observation were distinct, positive predictors for ulcer healing. Healing odds were 3.7 times higher for a decrease in MMP\u20101 and 2.1 times higher for a decrease in MMP\u20102 compared to the healing odds for a non\u2010decrease in MMP\u20101 and MMP\u20102. In conclusion, a decrease in MMP\u20101 and MMP\u20102, but not COX\u20102, in wound biopsy samples after 4\u2009weeks of observation can predict better healing of chronic venous ulcer.<\/jats:p>","DOI":"10.1111\/wrr.12915","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T07:14:10Z","timestamp":1616742850000},"page":"725-731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Matrix metalloproteinase (<scp>MMP<\/scp>)\u20101 and <scp>MMP<\/scp>\u20102, but not <scp>COX<\/scp>\u20102 serve as additional predictors for chronic venous ulcer healing"],"prefix":"10.1111","volume":"29","author":[{"given":"Aleksandra","family":"Bergant Suhodol\u010dan","sequence":"first","affiliation":[{"name":"Department of Dermatovenereology University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u0161tjan","family":"Luzar","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-8149","authenticated-orcid":false,"given":"Nada","family":"Kecelj Leskovec","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013825924765"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(99)70076-5"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"33S","article-title":"Care of venous leg ulcers","volume":"45","author":"Falanga 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