{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:15:10Z","timestamp":1785557710008,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T00:00:00Z","timestamp":1617926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pyoderma gangrenosum is a diagnosis of exclusion. It occurs rarely and is frequently misdiagnosed. It can result in severe tissue loss, particularly in surgical units with little experience. Nevertheless, surgical treatment might be necessary for reconstruction, once the progression of these wounds is controlled. We aimed to characterize medical findings in Pyoderma patients with extensive defects to assess the surgical procedures and their outcome. A retrospective study was conducted at our centre over an 18\u2010year period. Inclusion criteria were the diagnosis of Pyoderma gangrenosum and at least one surgical intervention. Descriptive statistics were used to analyse the data. Sixteen patients were included. The mean size of the lesions was noted with 12\u2009\u00d7\u20098 cm. Surgical procedures comprised debridements\/necrectomies, allograft conditioning, negative pressure wound therapy, skin grafts, and microvascular free flaps. Seven patients were discharged with healed wounds, six with minor wound healing disturbances. Three patients succumbed to their underlying diseases. Drug\u2010based therapy can stop the progress of Pyoderma, but severe tissue loss can be a persistent problem. According to our data, reconstructive\u2010surgical treatments (debridement, autologous and allogenous skin transplantation and microvascular free flaps) act as an integral component of the therapy and can be safe options for selected patients. Furthermore, we provide an algorithm that we follow at our department in severe cases.<\/jats:p>","DOI":"10.1111\/wrr.12918","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T14:34:13Z","timestamp":1617978853000},"page":"478-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The surgical approach to Pyoderma gangrenosum: A retrospective monocenter study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4057-0318","authenticated-orcid":false,"given":"Alperen S.","family":"Bingoel","sequence":"first","affiliation":[{"name":"Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Burn Center Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicco","family":"Krezdorn","sequence":"additional","affiliation":[{"name":"Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Burn Center Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kaltenborn","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopedic Surgery, Plastic, Hand and Reconstructive Surgery Armed Forces Hospital Westerstede  Westerstede Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Dastagir","sequence":"additional","affiliation":[{"name":"Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Burn Center Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Jokuszies","sequence":"additional","affiliation":[{"name":"Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Burn Center Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias R.","family":"Mett","sequence":"additional","affiliation":[{"name":"Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Burn Center Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, Burn Center Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,9]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","first-page":"655","article-title":"Pyoderma (Echthyma) gangraenosum: clinical an experimental observations in fice cases occuring in adults","volume":"22","author":"Brunsting LA","year":"1930","journal-title":"JAMA 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