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This role, linked to the presence of alpha smooth muscle actin, was very quickly confirmed and is part of the definition of granulation tissue myofibroblasts. However, myofibroblasts are cells that also play a much more central role in wound healing. Indeed, it has been shown that these cells produce large quantities of matrix components, and that they stimulate angiogenesis and can recruit immune cells. These actions take place via the secretion of molecules into their environment or indirectly via the production of microvesicles containing pro\u2010fibrotic and pro\u2010angiogenic molecules. Pathologically, granulation tissue can develop into a hypertrophic scar that histologically looks like granulation tissue, but which can remain for months or even years. It has been hypothesized that the myofibroblasts in these tissues remained present instead of disappearing by apoptosis, causing the maintenance of granulation tissue rather than allowing its change into a mature scar. Understanding the roles of both pathological and healthy myofibroblasts in wound tissue is crucial in order to better intervene in the healing mechanism.<\/jats:p>","DOI":"10.1111\/wrr.12919","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:39:59Z","timestamp":1619138399000},"page":"563-572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Granulation tissue myofibroblasts during normal and pathological skin healing: The interaction between their secretome and the microenvironment"],"prefix":"10.1111","volume":"29","author":[{"given":"Syrine","family":"Arif","sequence":"first","affiliation":[{"name":"Centre de recherche en organog\u00e9n\u00e8se exp\u00e9rimentale de l'Universit\u00e9 Laval\/LOEX Centre de recherche du CHU de Qu\u00e9bec\u2010Universit\u00e9 Laval  Quebec City Quebec 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