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Prolonged non\u2010healing wounds often lead to bacterial infections increasing the severity of wounds. Current treatment strategies for chronic wounds include debridement of wounds along with antibiotics, growth factors, and stem cell transplantation therapies. However, the compromised nature of autologous stem cells in patients with comorbidities such as diabetes limits the efficacy of the therapy. The discovery of induced pluripotent stem cell (iPSC) technology has immensely influenced the field of regenerative therapy. Enormous efforts have been made to develop integration\u2010free iPSCs suitable for clinical therapies. This review focuses on recent advances in the methods and reprogramming factors for generating iPSCs along with the existing challenges such as genetic alterations, tumorigenicity, immune rejection, and regulatory hurdles for the clinical application of iPSCs. Furthermore, this review also highlights the benefits of using iPSCs for the generation of skin cells and skin disease modeling over the existing clinical therapies for skin regeneration in chronic wounds and skin diseases.<\/jats:p>","DOI":"10.1111\/wrr.12925","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T11:55:01Z","timestamp":1620647701000},"page":"697-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Recent advances in the induced pluripotent stem cell\u2010based skin regeneration"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4665-7185","authenticated-orcid":false,"given":"Subholakshmi","family":"Choudhury","sequence":"first","affiliation":[{"name":"Department of Applied Biology Council of Scientific &amp; Industrial Research\u2010Indian Institute of Chemical Technology (CSIR\u2010IICT) Hyderabad India"},{"name":"Academy of 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