{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:26Z","timestamp":1787016146706,"version":"build-2736575974"},"reference-count":140,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["G\u201017\u20100018631"],"award-info":[{"award-number":["G\u201017\u20100018631"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000028","name":"Institute of Circulatory and Respiratory Health","doi-asserted-by":"publisher","award":["PJT\u2010162163"],"award-info":[{"award-number":["PJT\u2010162163"]}],"id":[{"id":"10.13039\/501100000028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008794","name":"Research Manitoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010318","name":"University of Manitoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Heart disease with attendant cardiac fibrosis kills more patients in developed countries than any other disease, including cancer. We highlight the recent literature on factors that activate and also deactivate cardiac fibroblasts. Activation of cardiac fibroblasts results in myofibroblasts phenotype which incorporates aSMA to stress fibres, express ED\u2010A fibronectin, elevated PDGFR\u03b1 and are hypersecretory ECM components. These cells facilitate both acute wound healing (infarct site) and chronic cardiac fibrosis. Quiescent fibroblasts are associated with normal myocardial tissue and provide relatively slow turnover of the ECM. Deactivation of activated myofibroblasts is a much less studied phenomenon. In this context, SKI is a known negative regulator of TGFb\n                    <jats:sub>1<\/jats:sub>\n                    \/Smad signalling, and thus may share functional similarity to PPAR\u03b3 activation. The discovery of SKI's potent anti\u2010fibrotic role, and its ability to deactivate and\/or myofibroblasts is featured and contrasted with PPAR\u03b3. While myofibroblasts are typically recruited from pools of potential precursor cells in a variety of organs, the importance of activation of resident cardiac fibroblasts has been recently emphasised. Myofibroblasts deposit ECM components at an elevated rate and contribute to both systolic and diastolic dysfunction with attendant cardiac fibrosis. A major knowledge gap exists as to specific proteins that may signal for fibroblast deactivation. As SKI may be a functionally pluripotent protein, we suggest that it serves as a scaffold to proteins other than R\u2010Smads and associated Smad signal proteins, and thus its anti\u2010fibrotic effects may extend beyond binding R\u2010Smads. While cardiac fibrosis is causal to heart failure, the treatment of cardiac fibrosis is hampered by the lack of availability of effective pharmacological anti\u2010fibrotic agents. The current review will provide an overview of work highlighting novel factors which cause fibroblast activation and deactivation to underscore putative therapeutic avenues for improving disease outcomes in cardiac patients with fibrosed hearts.\n                  <\/jats:p>","DOI":"10.1111\/wrr.12947","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T10:14:09Z","timestamp":1622628849000},"page":"667-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Novel factors that activate and deactivate cardiac fibroblasts: A new perspective for treatment of cardiac fibrosis"],"prefix":"10.1111","volume":"29","author":[{"given":"Rebeca","family":"de Oliveira Camargo","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Sciences, Albrechtsen Research Centre  Winnipeg Canada"},{"name":"Department of Physiology and Pathophysiology University of Manitoba  Winnipeg Canada"},{"name":"Rady Faculty of Health Sciences, Max Rady College of Medicine University of Manitoba  Winnipeg Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Besher","family":"Abual'anaz","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, Albrechtsen Research Centre  Winnipeg Canada"},{"name":"Department of Physiology and Pathophysiology University of Manitoba  Winnipeg Canada"},{"name":"Rady Faculty of Health Sciences, Max Rady College of Medicine University of Manitoba  Winnipeg Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil G.","family":"Rattan","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, Albrechtsen Research Centre  Winnipeg Canada"},{"name":"Department of Physiology and Pathophysiology University of Manitoba  Winnipeg Canada"},{"name":"Rady Faculty of Health Sciences, Max Rady College of Medicine University of Manitoba  Winnipeg Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista L.","family":"Filomeno","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, Albrechtsen Research Centre  Winnipeg Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3763-5961","authenticated-orcid":false,"given":"Ian M. C.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, Albrechtsen Research Centre  Winnipeg Canada"},{"name":"Department of Physiology and Pathophysiology University of Manitoba  Winnipeg Canada"},{"name":"Rady Faculty of Health Sciences, Max Rady College of Medicine University of Manitoba  Winnipeg Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"issue":"229","key":"e_1_2_13_2_1","first-page":"1","article-title":"Mortality in the United States, 2014","author":"Murphy SL","year":"2015","journal-title":"NCHS Data Brief"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162488599"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021119-034527"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-1003"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307778"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa324"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0324-5"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370213489441"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.07.014"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010013"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071297"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.201293"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.142.3.873"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2015.05.004"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.03.001"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00050.2010"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181945"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.149047"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07511"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-017-0659-5"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12392"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.2511"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.05.007"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.608569"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00840-w"},{"issue":"928547","key":"e_1_2_13_27_1","article-title":"Citrus alkaline extracts inhibit senescence of A549 cells to alleviate pulmonary fibrosis via the \u03b2\u2010catenin\/P53 pathway","volume":"27","author":"Han D","year":"2021","journal-title":"Med Sci Monit"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.126722"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2013.10.006"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00266.2001"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00910.2006"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00584.2015"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1998.0902"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00035-3"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI94753"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(94)00194-8"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/17.14.5489"},{"issue":"1","key":"e_1_2_13_38_1","first-page":"67","article-title":"Xenopus c\u2010ski contains a novel coiled\u2010coil protein domain, and is maternally expressed during development","volume":"8","author":"Sleeman JP","year":"1993","journal-title":"Oncogene"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132318"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.090097797"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303447200"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-018-0015-8"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.9.1462"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.49.35269"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80201-4"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.9.892"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2412"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2421"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.61"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.4.5"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-019-0432-z"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0006OC"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323000803600216"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9112367"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249436"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.318062"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/318134"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.03.027"},{"key":"e_1_2_13_59_1","first-page":"394","volume-title":"Heart Disease","author":"Colucci WS","year":"1997"},{"key":"e_1_2_13_60_1","first-page":"279","volume-title":"Heart Failure. Scientific Principles and Clinical Practice","author":"Kannel WB","year":"1997"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-006-0072-7"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02677.x"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000155333.69009.63"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000130526.20854.fa"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0047"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.5.2273"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910213411706"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.62.1.289"},{"issue":"3","key":"e_1_2_13_69_1","first-page":"364","article-title":"The collagen network of the heart","volume":"40","author":"Caulfield JB","year":"1979","journal-title":"Lab Invest"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1684"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.21274"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00370"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.10.022"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.6.1849"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-5385-4_6"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.001af.x"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(88)80059-2"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(98)00264-8"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4246"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306565"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00434-5"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.11.4065"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/28.9.1423"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3020527"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.11.026"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21134"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.18.3285"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.9.4219"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(02)00015-0"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22280"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.78.2.173"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(08)80003-X"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.2.133"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)35666-1"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0347"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb17931.x"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)36699-1"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200704042"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210855200"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(97)01036-2"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/40290"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.5.2896"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/383691a0"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80120-3"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.14.2144"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81696-7"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.67.1.753"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81556-1"},{"issue":"1","key":"e_1_2_13_109_1","first-page":"9","article-title":"Fine tuning and cross\u2010talking of TGF\u2010beta signal by inhibitory Smads","volume":"38","author":"Park SH","year":"2005","journal-title":"J Biochem Mol Biol"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21255"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.21.13053"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.14769"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109826"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.06.015"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.06.007"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.09.049"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42595"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015050499"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109802"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.329763.119"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02219-9"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M900843200"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C110.212621"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63598-5"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.060"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2019.02.006"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.235531"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1722"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37089"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84161-5"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2017.03.011"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-6657-4_4"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2940271"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000142607.33398.54"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06265"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12260"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5308"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx001"},{"issue":"18","key":"e_1_2_13_139_1","first-page":"5358","article-title":"Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility","volume":"62","author":"Gillan L","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1494-y"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00033.2018"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12947","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.12947","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T06:53:55Z","timestamp":1693378435000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,16]]},"references-count":140,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/wrr.12947"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12947","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,16]]},"assertion":[{"value":"2021-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}