{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:41:11Z","timestamp":1783406471222,"version":"3.54.6"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with a diabetic foot ulcer (DFU) suffer disabilities and are at increased risk for lower extremity amputation. Current standard of care includes debridement, topical antibiotics, and weight off\u2010loading\u2014still resulting in low rates of healing. Previous small\u2010scale research has indicated that repeated remote ischemic conditioning (rRIC) is a novel modality that delivers significantly higher DFU healing rates. This proof\u2010of\u2010concept study was performed to expand the research on the utility of rRIC as an adjunctive treatment in the healing of chronic DFUs. Forty subjects (41 wounds) received rRIC treatment three times weekly in addition to standard of care for 12\u2009weeks. Subjects that did not heal in this time frame but had a significant reduction in wound size were eligible to continue for an 8\u2010week extension period. By the end of the extension period, 31 of the 41 DFU wounds (75.6%) in this study were determined to be healed. This compares favourably to the 25\u201330% standard of care average healing rate. For additional comparison, another group of patients receiving standard of care alone, by the same investigator, was selected and matched by wound size at baseline and wound location. For this matching cohort, after 20\u2009weeks of treatment, only 15 of the 41 DFU comparison wounds (36.6%) were determined to be healed, in line with other standard of care results. In the rRIC treatment group, the 10 wounds that did not heal, experienced an average reduction in wound area of 54.3%. The results of this proof\u2010of\u2010concept study reinforce earlier evidence that the addition of rRIC to local wound care significantly improves the healing of chronic diabetic foot ulcers.<\/jats:p>","DOI":"10.1111\/wrr.12956","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T12:30:35Z","timestamp":1625747435000},"page":"853-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of repeated remote ischemic conditioning on diabetic foot ulcers: A <scp>proof\u2010of\u2010concept<\/scp> study"],"prefix":"10.1111","volume":"29","author":[{"given":"Matthew","family":"Regulski","sequence":"first","affiliation":[{"name":"Wound Institute of Ocean County  Toms River New Jersey USA"},{"name":"The Center for Wound Healing and Hyperbaric Medicine Community Medical Center  Toms River New Jersey USA"},{"name":"Kimball Medical Center  Lakewood New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8266-6428","authenticated-orcid":false,"given":"Todd","family":"Greenwood","sequence":"additional","affiliation":[{"name":"LifeCuff Technologies, Inc.  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Leschinsky","sequence":"additional","affiliation":[{"name":"LifeCuff Technologies, Inc.  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-016-0444-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.7547\/15-172"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296815584796"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0177916"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5758\/vsi.2018.34.4.109"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13047-020-00383-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.03.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2017.0743"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.10.1835"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(01)00217-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3264-0"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.161"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2016.03.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(02)00815-2"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12269"},{"key":"e_1_2_8_18_1","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research Center for Biologics Evaluation and Research Center for Devices and Radiological Health.Guidance for industry chronic cutaneous ulcer and burn wounds\u2014developing products for treatment.2006;https:\/\/www.fda.gov\/media\/71278\/download. 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