{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:31:46Z","timestamp":1787157106380,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A multicenter, phase 4, randomized, comparative\u2010efficacy study in subjects with lower extremity wounds was carried out to compare wound closure rates, for a single\u2010use negative pressure wound therapy (s\u2010NPWT) versus traditional NPWT (t\u2010NPWT) systems over a 12\u2010week treatment period. From the initial population of patients with diabetic foot ulcers (DFU) and venous leg ulcers (VLU), we analyzed a subgroup of patients with diabetes mellitus and leg and foot ulcers (either DFUs or VLUs in diabetics), termed, the diabetic lower extremity ulcers (DLEU). In the DLEU group, there were 95 patients in intention\u2010to\u2010treat (ITT) and 61 patients in per protocol (PP) populations, respectively. We found a significant difference in favor of s\u2010NPWT over t\u2010NPWT in the confirmed wound closures at 12\u2009weeks both in ITT (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and PP populations (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.017). Significantly higher wound closure rates in s\u2010NPWT group suggest that s\u2010NPWT should be preferred NPWT option for DLEU.\n                  <\/jats:p>","DOI":"10.1111\/wrr.12966","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T12:00:47Z","timestamp":1631707247000},"page":"908-911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A prospective, randomized, controlled clinical study on the effectiveness of a single\u2010use negative pressure wound therapy system, compared to traditional negative pressure wound therapy in the treatment of diabetic ulcers of the lower extremities"],"prefix":"10.1111","volume":"29","author":[{"given":"Robert S.","family":"Kirsner","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0544-3321","authenticated-orcid":false,"given":"Dmitry","family":"Zimnitsky","sequence":"additional","affiliation":[{"name":"Global Clinical Strategy Smith+Nephew  Cary North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Robinson","sequence":"additional","affiliation":[{"name":"Global Data Analytics Smith+Nephew  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"DriscollPWound prevalence and wound management 2012\u20132020. Mediligence. 2013. blog.mediligence.com Accessed May 20 2018."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.10.003"},{"key":"e_1_2_10_4_1","first-page":"52","article-title":"Use of PICO\u2122 to improve clinical and economic outcomes in hard\u2010to\u2010heal wounds","volume":"8","author":"Dowsett C","year":"2017","journal-title":"Wounds Int"},{"key":"e_1_2_10_5_1","article-title":"Biological effects of a disposable, canisterless negative pressure wound therapy system","volume":"14","author":"Malmsj\u00f6 M","year":"2014","journal-title":"Eplasty"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.25270\/owm.2018.1.2833"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtv.2011.07.002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2011.06.001"},{"issue":"3","key":"e_1_2_10_9_1","first-page":"30","article-title":"Use of a portable, single use negative pressure wound therapy device in home care patients with low to moderately exuding wounds: a case series","volume":"60","author":"Hurd T","year":"2014","journal-title":"Ostomy Wound Manag"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12727"},{"key":"e_1_2_10_11_1","first-page":"36","article-title":"Impact of a single\u2010use negative pressure wound therapy system on healing","volume":"34","author":"McCluskey P","year":"2020","journal-title":"JCN"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001560"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15413"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113709"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.7748\/ns.25.45.41.s48"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2020.1218"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/wrr.12966","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.12966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:11:43Z","timestamp":1787155903000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.12966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/wrr.12966"],"URL":"https:\/\/doi.org\/10.1111\/wrr.12966","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]},"assertion":[{"value":"2021-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}