{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:55:42Z","timestamp":1791860142014,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T00:00:00Z","timestamp":1632528000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To investigate whether the addition of human recombinant epidermal growth factor (h\u2010EGF) to 2% carboxymethyl cellulose gel is more effective in diabetic wound healing than standard treatment, a pilot, double\u2010blind, randomized and controlled clinical trial with therapeutic intervention was performed at a university hospital. The sample consisted of 25 patients (14 in the intervention group that used rh\u2010EGF and 11 in the control group that used 2% carboxymethyl cellulose gel). Data were tabulated in SPSS and analysed by intention to treat, without loss or exclusion of participants. Twenty\u2010five subjects participated with a mean age of 60.6\u2009years, a predominance of males in both groups and 100% prevalence of type\u20102 diabetes. Within 12\u2009weeks, complete wound healing occurred in three ulcers in the intervention group versus one ulcer in the control group. The percent reduction in the wound area was significantly higher in the intervention group than in the control group (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.049). Concerning the types of tissue, an increase in granulation and epithelial tissue and a reduction in exudate levels were observed in both groups. Decreased slough occurred only in the intervention group. No participant experienced serious or local adverse events during the study period. This study shows that h\u2010EGF is effective, with a statistically significant reduction in wound area, improvement of tissue quality, and safe treatment of chronic wounds. In addition, this study demonstrated that blinding of participants during research using h\u2010EGF is feasible.\n                  <\/jats:p>","DOI":"10.1111\/wrr.12969","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T18:24:05Z","timestamp":1632594245000},"page":"920-926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["<scp>Effectiveness of<\/scp>\n                    a\n                    <scp>synthetic human recombinant epidermal growth factor in diabetic patients wound healing<\/scp>\n                    :\n                    <scp>Pilot<\/scp>\n                    ,\n                    <scp>double\u2010blind<\/scp>\n                    ,\n                    <scp>randomized clinical controlled trial<\/scp>"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6348-3287","authenticated-orcid":false,"given":"Bianca Campos","family":"Oliveira","sequence":"first","affiliation":[{"name":"Doctoral student in Health Care Sciences Federal Fluminense University  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7494-7457","authenticated-orcid":false,"given":"Beatriz Guitton Renaud Baptista","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Full Professor at Universidade Federal Fluminense Coordinator of the Graduate Program in Health Care Sciences, Federal Fluminense University, Health Area Coordinator \u2010 FAPERJ  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4618-439X","authenticated-orcid":false,"given":"Gabriela","family":"Deutsch","sequence":"additional","affiliation":[{"name":"PhD in Sciences Applied to Health Products Federal Fluminense University  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Soares","family":"Pessanha","sequence":"additional","affiliation":[{"name":"PhD in Health Care Sciences Federal Fluminense University  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma Rodrigues","family":"de Castilho","sequence":"additional","affiliation":[{"name":"Full Professor at Federal Fluminense University Director of the College of Pharmacy, Federal Fluminense University  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2018.10.005"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2020.29.Sup9b.S1"},{"key":"e_1_2_9_4_1","first-page":"15","article-title":"Skin acute wound healing: a comprehensive review","volume":"1","author":"Ca\u00f1edo\u2010Dorantes L","year":"2019","journal-title":"Int J Inflam"},{"key":"e_1_2_9_5_1","first-page":"17","article-title":"From inflammation to current and alternative therapies involved in wound healing","volume":"1","author":"Serra MB","year":"2017","journal-title":"Int J Inflam"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-019-09492-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7219-7_12"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36268"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.09.219"},{"key":"e_1_2_9_10_1","first-page":"20","article-title":"Management of a non\u2010healing postoperative wound using a bacteria and fungi\u2010binding mesh","volume":"5","author":"Lund H","year":"2014","journal-title":"Int Wound 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