{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T16:33:09Z","timestamp":1787157189430,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The incidence of diabetes is increasing worldwide with concomitant raising number of patients with diabetic foot disease. Diabetic foot disease treatment has received more attention in the past decades, culminating in the creation of multidisciplinary outpatient clinics, but at the same time, complexity of patients seems to have increased. The aim of this article is to study differences in patient characteristics and outcomes (ulcer healing and ulcer\u2010free survival days) in patients with a diabetic foot ulcer in two prospective cohorts with 15\u2009years in between. Prospective cohort study of all patients in one diabetic foot centre of expertise in 2003\u20132004 and 2014\u20132018. Clinical outcomes were determined after a follow\u2010up period of 12\u2009months. Outcomes were differences in baseline characteristics and comorbidities, and differences in ulcer\u2010related outcomes between both cohorts. We included all consecutive diabetic foot ulcer patients from our centre for the period 2003\u20132004 (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a079) and 2014\u20132018 (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0271). Age (67.0\u2009\u00b1\u200914.3 vs. 71.6\u2009\u00b1\u200911.5,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.003) and prevalence of end\u2010stage renal disease (1.3% vs. 7.7%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.036) were significantly higher in the more recent population. The more recent population had higher healing rate (53.2% vs. 76.4%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), higher median ulcer\u2010free survival days once an ulcer had healed [173\u2009days (IQR 85.3\u2013295.5) vs. 257.0 (IQR 157.0\u2013318.0),\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.026], and fewer minor amputations (20.3% vs. 8.1%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.002). People with diabetic foot ulcers treated in 2014\u20132018 were older and more frequently diagnosed with ESRD, compared to this population in 2003\u20132004, while other characteristics were similar; ulcer\u2010related outcomes were better.\n                  <\/jats:p>","DOI":"10.1111\/wrr.12976","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T07:25:51Z","timestamp":1634801151000},"page":"912-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Improved outcomes in patients with diabetic foot ulcers despite of differences in baseline characteristics"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7367-962X","authenticated-orcid":false,"given":"Afram","family":"Rumanes","sequence":"first","affiliation":[{"name":"Department of Surgery Ziekenhuisgroep Twente (ZGT)  Almelo and Hengelo The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap J.","family":"van Netten","sequence":"additional","affiliation":[{"name":"Department of Surgery Ziekenhuisgroep Twente (ZGT)  Almelo and Hengelo The Netherlands"},{"name":"Department of Rehabilitation, Amsterdam Movement Sciences Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"},{"name":"School of Public Health Queensland University of Technology  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marloes","family":"Vermeer","sequence":"additional","affiliation":[{"name":"ZGT Academy Ziekenhuisgroep Twente (ZGT), Almelo and Hengelo  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rombout R.","family":"Kruse","sequence":"additional","affiliation":[{"name":"Department of Surgery Ziekenhuisgroep Twente (ZGT)  Almelo and Hengelo The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas C.","family":"Schaper","sequence":"additional","affiliation":[{"name":"Division of Endocrinology MUMC+, CARIM and CAPHRI Institute  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette J. 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C.","family":"van Gemert\u2010Pijnen","sequence":"additional","affiliation":[{"name":"Persuasive Health Technology, University of Twente  Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff G.","family":"van Baal","sequence":"additional","affiliation":[{"name":"Department of Surgery Ziekenhuisgroep Twente (ZGT)  Almelo and Hengelo The Netherlands"},{"name":"ZGT Academy Ziekenhuisgroep Twente (ZGT), Almelo and Hengelo  The Netherlands"},{"name":"University of Cardiff  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2699"},{"issue":"2","key":"e_1_2_8_3_1","first-page":"16","article-title":"Management of Diabetic Foot Ulcers: a review","volume":"33","author":"Frykberg Robert G","year":"2016","journal-title":"Fed Pr"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67698-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/383275"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3402\/dfa.v4i0.21847"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2007.00392.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.06.003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci18-0007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12545"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1614"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.02.023"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-7560(200009\/10)16:1+\u2329::AID-DMRR113\u232a3.0.CO;2-S"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4711-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0130609"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2015.10.003"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2008.11.025"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310799"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6429575"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-0940-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13199"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2008.02445.x"},{"key":"e_1_2_8_24_1","unstructured":"Dutch Society for Vascular.Diabetic foot guideline. 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