{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:25:33Z","timestamp":1790821533485,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T00:00:00Z","timestamp":1634947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T00:00:00Z","timestamp":1634947200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Many patients with venous leg ulcers do not reach complete healing with compression treatment alone, which is current standard care. This clinical trial HEAL LL\u201037 was a phase IIb double\u2010blind, randomized, placebo\u2010controlled study, with the aim to evaluate the efficacy and safety of a new drug LL\u201037 for topical administration, in combination with compression therapy, in 148 patients suffering from hard\u2010to\u2010heal venous leg ulcers. The study had three arms, consisting of two groups treated with LL\u201037 at concentrations of 0.5 or 1.6\u00a0mg\/mL, and a placebo cohort. Patients had a mean age of 67.6\u2009years, a median ulcer duration of 20.3\u00a0months, and a mean wound size at the time of randomization of 11.6\u00a0cm\n                    <jats:sup>2<\/jats:sup>\n                    . Efficacy analysis performed on the full study population did not identify any significant improvement in healing in patients treated with LL\u201037 as compared with the placebo. In contrast, a post hoc analysis revealed statistically significant improvement with LL\u201037 treatment in several interrelated healing parameters in the subgroup of patients with large target wounds (a wound area of at least 10\u00a0cm\n                    <jats:sup>2<\/jats:sup>\n                    at randomization), which is a known negative prognostic factor for healing. The study drug was well tolerated and safe in both dose strengths. In summary, this clinical trial did not detect any significant differences in healing of venous lower leg ulcers in the entire study cohort comparing patients treated with LL\u201037 versus placebo. A subgroup analysis provided an interesting observation that LL\u201037 could offer a treatment benefit in patients with large ulcers, exigently warranting a further study adequately powered to statistically assess the treatment outcome in this patient group.\n                  <\/jats:p>","DOI":"10.1111\/wrr.12977","type":"journal-article","created":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T05:54:15Z","timestamp":1634968455000},"page":"938-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Evaluation of\n                    <scp>LL<\/scp>\n                    \u201037 in healing of\n                    <scp>hard\u2010to\u2010heal<\/scp>\n                    venous leg ulcers: A multicentric prospective randomized\n                    <scp>placebo\u2010controlled<\/scp>\n                    clinical 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