{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:37:04Z","timestamp":1787067424694,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We aimed to validate the prognostic value of subclassifying moderate diabetic foot infections into two categories: moderate and moderate\/severe. We conducted a prospective study of a cohort of 200 patients with moderate and severe infections. Moderate infections were subclassified after applying a previously published score. Variables associated with prognosis were: need for any amputation, major amputation, need for hospitalisation, length of hospitalisation, length of antibiotic therapy, reinfection rate and infection\u2010related mortality. Infections were moderate in 111 cases (55.5%) and severe in 89 (44.5%). Osteomyelitis (OM) was diagnosed in 114 cases (57%), 73 moderate (36.5%) and 41 severe (20.5%). Patients with severe OM had a higher rate of amputations, major amputations, hospitalisations and need for antibiotic therapy, and a longer duration of antibiotics when compared with moderate OM. After applying the score, moderate infections were subclassified into 73 moderate cases (65.7%) and 38 moderate\/severe cases (34.3%). Moderate\/severe had a higher rate of amputations, major amputations, hospitalisations and need for antibiotics than moderate ones. No differences regarding prognosis were found between moderate\/severe and severe infections with systemic inflammatory response syndrome. Moderate\/severe diabetic foot infections, which could also be known as severe infections without systemic inflammatory response syndrome, should be recognised as a new subgroup. We propose to merge severe diabetic foot infections with and without systemic inflammatory response syndrome into a unique category due to its prognostic value. Furthermore, OM should be added to both moderate and severe new categories of diabetic foot infections.<\/jats:p>","DOI":"10.1111\/wrr.13038","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T11:03:25Z","timestamp":1657969405000},"page":"553-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Severe diabetic foot infections without systemic inflammatory response syndrome: Prospective validation of a new category"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-5040","authenticated-orcid":false,"given":"Javier","family":"Arag\u00f3n\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Surgery, Diabetic Foot Unit La Paloma Hospital Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0028-765X","authenticated-orcid":false,"given":"Gerardo","family":"V\u00edquez\u2010Molina","sequence":"additional","affiliation":[{"name":"Diabetic Foot Unit San Juan de Dios Hospital San Jos\u00e9 de Costa Rica Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9530-9729","authenticated-orcid":false,"given":"Mar\u00eda Eugenia","family":"L\u00f3pez\u2010Valverde","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Service Juan Ram\u00f3n Jimenez Hospital Huelva Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3812-6966","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Rojas\u2010Bonilla","sequence":"additional","affiliation":[{"name":"Diabetic Foot Unit San Juan de Dios Hospital San Jos\u00e9 de Costa Rica Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis346"},{"issue":"1","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3280","article-title":"Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update)","volume":"36","author":"Lipsky BA","year":"2020","journal-title":"Diabetes Metab Res 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