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With an appropriate search strategy, 7 studies were selected for analysis (2 RCTs and 5 cohort studies). The result showed that the application of ALBS effectively reduced the length of hospital stay (WMD \u22125.55; 95% CI: \u22129.85 to \u22121.26;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01), the recurrence rates (RR 0.33; 95% CI: 0.15 to 0.69;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) and the mortality rates (RR 0.22; 95% CI: 0.06 to 0.82;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). Compared to the control group<jats:styled-content>s<\/jats:styled-content>, however, there was no difference in healing rates (RR 1.06; 95% CI: 0.96 to 1.18;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.26), healing time (WMD \u22121.44; 95% CI: \u22123.37 to \u22120.49;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.14), the number of debridement (WMD \u22121.98; 95% CI: \u22124.08 to 0.12;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.06) and major amputation rates (RR 0.76; 95% CI: 0.35 to 1.61;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.47). The ALBS appears to have some beneficial effects as an adjunct to standard surgery in the treatment of DFI with or without osteomyelitis, as it reduces recurrence rates, mortality rates, and length of hospital stay, but there was no statistically significant difference in enhancing wound healing.<\/jats:p>","DOI":"10.1111\/wrr.13061","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T08:34:01Z","timestamp":1671093241000},"page":"205-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antibiotic\u2010loaded bone substitutes therapy in the management of the moderate to severe diabetic foot infection: A meta\u2010analysis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4787-7267","authenticated-orcid":false,"given":"Xinyi","family":"Lin","sequence":"first","affiliation":[{"name":"Guangzhou Women and Children's Medical Center Guangzhou 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