{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:58:01Z","timestamp":1781657881898,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Our main objective was to<\/jats:italic> validate that hyperspectral imaging via a new portable camera carries the potential to provide a reliable clinical biomarker that can predict DFU healing. We recruited patients with diabetic foot ulceration (DFU) without peripheral arterial disease, infection or other serious illness. Using an hyperspectral imaging (HSI) apparatus, post\u2010debridement hyperspectral images were taken evaluating the ulcer size, periwound oxyhemoglobin (OxyHb), deoxyhemoglobin level (DeoxyHb) and oxygen saturation (O<jats:sub>2<\/jats:sub>Sat) for four consecutive visits. Twenty\u2010seven patients were followed, out of whom seven healed their DFU while the remaining 20 failed to heal their DFU. The average time between each visit was 3\u2009weeks. Binary logistic regression of healers versus non\u2010healers on Visit 1 oxyHb and on Visit 2 showed a significant inverse association, OR\u00a0=\u00a00.85 (95% CI: 0.73\u20130.98, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). An inverse correlation was observed between the Visit 1 oxyHb and the percentage of ulcer size reduction between Visit 1 and Visit 4 (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.46, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02) and between the Visit 2 oxyHb and the percentage of ulcer size reduction between Visits 2 and 4 (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.65, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). Using oxyHb 50 as the cut\u2010off point to predict DFU complete healing, Visit 1 oxyHb measurement provided 85% sensitivity, 70% specificity, 50% positive predictive value and 93% negative predictive value. For Visit 2, oxyHb had 85% sensitivity, 85% specificity, 66% positive predictive value and 94% negative predictive value. We conclude that this preliminary study, which involved a relatively small number of patients, indicates that hyperspectral imaging is a simple exam that can easily be added to daily clinical practice and has the potential to provide useful information regarding the healing potential of DFU over a short period of time.<\/jats:p>","DOI":"10.1111\/wrr.13071","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T15:54:11Z","timestamp":1673538851000},"page":"199-204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Use of hyperspectral imaging to predict healing of diabetic foot ulceration"],"prefix":"10.1111","volume":"31","author":[{"given":"Konstantinos","family":"Kounas","sequence":"first","affiliation":[{"name":"Joslin\u2010Beth Israel Deaconess Foot Center and Microcirculation Lab, Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts 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