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Fifty\u2010two skin samples (26 normal skin, 26 burn scars) were collected from 26 burn patients (12 male, 14 female) and microbiota analysis was performed. The correlation between skin microbiota and biomechanical properties of burn scars was also investigated. There were no significant differences in clinical characteristics between male and female patients. Considering the biomechanical properties of burn scars and normal skin around it performed before sample collection, the mean erythema level of men's normal skin was significantly higher than that of women, whereas the mean levels of melanin, transepidermal water loss and skin hydration showed no significant sex differences. The erythrocyte sedimentation rate was significantly higher in females than that in males. Alpha diversity showed no significant differences between normal skin and burn scars in the male group. However, the scar was significantly higher than that of normal skin in the female group. Microbial network analysis revealed that the male group had more complex microbial network than the female group. Additionally, in the male group, the edge density and clustering coefficient were higher in burn scars when compared to normal skin, than the female group. There were sex differences in the results of microbiome of normal skin and burn scars. Some of the altered microbiota have been correlated with the biomechanical properties of burn scars. In conclusion, sex difference in the burn scar microbiome was confirmed. These results suggest that burn treatment strategies should vary with sex.<\/jats:p>","DOI":"10.1111\/wrr.13088","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T09:53:51Z","timestamp":1683021231000},"page":"547-558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sex differences in the skin microbiome of burn scars"],"prefix":"10.1111","volume":"31","author":[{"given":"Yeongyun","family":"Jung","sequence":"first","affiliation":[{"name":"Burn Institute, Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital Hallym University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui Song","family":"Cui","sequence":"additional","affiliation":[{"name":"Burn Institute, Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital Hallym University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Young","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital Hallym University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Burn Institute, Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital Hallym University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4091-6382","authenticated-orcid":false,"given":"Cheong Hoon","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital Hallym University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9959-3285","authenticated-orcid":false,"given":"Yoon Soo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital Hallym University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,24]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"243","article-title":"Burns in the third world: an unmet need","volume":"30","author":"Stokes M","year":"2017","journal-title":"Ann Burns Fire Disasters"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01105.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.03.006"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002722"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000323"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0145-5"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2537"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.157"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10834-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00695-20"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13451"},{"key":"e_1_2_11_13_1","first-page":"4","article-title":"The molecular basis of hypertrophic scars. 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