{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:42:43Z","timestamp":1788316963544,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Basic inflammatory markers have been extensively studied to differentiate between non\u2010infected and infected diabetic foot ulcers (DFUs). Very rarely, basic haematological tests such as white cell count (WCC) and platelet counts were used as performance markers for DFU infection severity. The aim is to investigate these biomarkers in patients with DFU treated exclusively with surgery. In this retrospective comparative study, we included 154 procedures comparing a conservative surgery group (<jats:italic>n<\/jats:italic>\u2009=\u200966 for infected DFU) and a minor amputation group (<jats:italic>n<\/jats:italic>\u2009=\u200988 for infected DFU with osteomyelitis). Outcomes were set as the preoperative values of: WCC, neutrophils (N), lymphocytes (L), Monocytes (M), Platelets (P), red cell distribution width (RDW) and the ratios N\/L, L\/M and P\/L. Area under curve (AUC) of the receiver operating characteristic (ROC) was calculated based on the diagnosis of minor amputation as a positive result. Cutoff point values with the highest sensitivity and specificity were obtained for each outcome. The highest AUC values were for WCC (0.68), neutrophils (0.68), platelets (0.7) and P\/L ratio (0.69) with corresponding cut\u2010off values of 10,650\/mm<jats:sup>3<\/jats:sup>, 76%, 234,000\/mcL and 265, respectively. The highest sensitivity was for the platelet count (81.5%) while the highest specificity was for L\/M (89%) and P\/L ratios (87%). Postoperative values showed similar results. Simple routine blood tests could serve as inflammatory performance markers to help predict the severity of infection in patients treated surgically for infected DFU.<\/jats:p>","DOI":"10.1111\/wrr.13104","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T16:59:36Z","timestamp":1687021176000},"page":"627-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Basic haematological tests as inflammatory performance markers of patients treated either by conservative surgery or minor amputation for infected diabetic foot ulcers"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0094-9892","authenticated-orcid":false,"given":"Kaissar","family":"Yammine","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Lebanese American University Medical Center\u2010Rizk Hospital, Lebanese American University, School of Medicine  Beirut Lebanon"},{"name":"Diabetic Foot Clinic, Lebanese American University Medical Center\u2010Rizk Hospital  Beirut Lebanon"},{"name":"Center for Evidence\u2010Based Anatomy, Sport &amp; Orthopedics Research  Jdeideh Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghadi","family":"Abou Orm","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Lebanese American University Medical Center\u2010Rizk Hospital, Lebanese American University, School of Medicine  Beirut Lebanon"},{"name":"Center for Evidence\u2010Based Anatomy, Sport &amp; Orthopedics Research  Jdeideh Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Mouawad","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Lebanese American University Medical Center\u2010Rizk Hospital, Lebanese American University, School of Medicine  Beirut Lebanon"},{"name":"Center for Evidence\u2010Based Anatomy, Sport &amp; Orthopedics Research  Jdeideh Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chahine","family":"Assi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Lebanese American University Medical Center\u2010Rizk Hospital, Lebanese American University, School of Medicine  Beirut Lebanon"},{"name":"Center for Evidence\u2010Based Anatomy, Sport &amp; Orthopedics Research  Jdeideh Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41598\u2010020\u201071908\u20109"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16\u20100806"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1615439"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/DMRR.3280"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3402\/dfa.v5.24445"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19\u20101614"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13047\u2010019\u20100345\u2010y"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2020.07.086"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.RVW.19.00162"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734619888361"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1938640018819784"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1938640019857795"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.JFAS.2020.04.025"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734620923425"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fas.2021.03.008"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/OFID\/OFY210.313"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734613486152"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734617700539"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/JRMS.JRMS_810_16"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2017.6981"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/J.JFAS.2018.12.010"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347346211057742"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S284583"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.DIABRES.2018.08.009"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/JCLA.23719"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1507\/ENDOCRJ.EJ18\u20100477"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JVS.2016.08.108"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2017.6981"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/2473011421S00388"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734620904819"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2727.199625"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.13104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T04:57:29Z","timestamp":1703307449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.13104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,26]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/wrr.13104"],"URL":"https:\/\/doi.org\/10.1111\/wrr.13104","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,26]]},"assertion":[{"value":"2022-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}