{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:07:32Z","timestamp":1747188452149,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Debate persists regarding the safety of hypochlorite\u2010containing solutions in the decontamination of infected wounds. In 2006, the Israeli Ministry of Health withdrew licensing approval for troclosene sodium as a wound irrigation solution. The aim of this prospective clinical and laboratory study was to investigate the safety of troclosene sodium solution for decontamination of infected wounds. Troclosene sodium solution was used to treat 30 patients with 35 infected skin wounds of various etiologies and body areas, over a treatment period of 8\u2009days. Data were gathered according to a prospectively designed protocol including general findings, wound\u2010specific observations on Day 1 and Day 8 and laboratory parameters on Day 1 and Day 8. Wound swabs and tissue biopsy for culture were taken on Day 1 and Day 8. Statistical analysis was executed. Tests were 2\u2010sided and <jats:italic>p<\/jats:italic> values of &lt;0.05 were considered statistically significant. Eighteen males and 12 females, with 35 infected skin wounds were enrolled. There were no adverse clinical events. No significant changes were observed in general clinical observations. Statistically significant improvements were observed in: pain (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.0001); edema (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.0001); area of wound covered by granulation tissue (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.0001); exudate (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.0001); and erythema (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). Prior to treatment, bacteria were demonstrated on microscopy or on culture in 90% of wound samples. On Day 8, this frequency reduced to 40%. There were no abnormal laboratory tests. Serum sodium concentration increased significantly between Day 1 and Day 8, whilst serum concentration of urea and concentrations of thrombocytes, leucocytes and neutrophils showed statistically significant reductions, but all values remained within normal laboratory ranges throughout the study period. Troclosene sodium solution is clinically safe in the management of infected wounds. These findings were presented to the Israel Ministry of Health and as a result, troclosene sodium was re\u2010approved and licensed for decontamination of infected wounds in Israel.<\/jats:p>","DOI":"10.1111\/wrr.13105","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T14:04:24Z","timestamp":1687788264000},"page":"635-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety of troclosene sodium solution in decontamination of wounds: A prospective clinical and laboratory study"],"prefix":"10.1111","volume":"31","author":[{"given":"Miriam","family":"Segal","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery The Lady Davis Carmel Medical Center  Haifa Israel"},{"name":"Ruth and Bruce Rappaport Faculty of Medicine, Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issa","family":"Metanes","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The Lady Davis Carmel Medical Center  Haifa Israel"},{"name":"Ruth and Bruce Rappaport Faculty of Medicine, Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciaran P.","family":"O'Boyle","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals NUHS Trust The University of Nottingham  Nottingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Sadeh","sequence":"additional","affiliation":[{"name":"Ruth and Bruce Rappaport Faculty of Medicine, Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The Lady Davis Carmel Medical Center  Haifa Israel"},{"name":"Ruth and Bruce Rappaport Faculty of Medicine, Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonid","family":"Bryzgalin","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The Lady Davis Carmel Medical Center  Haifa Israel"},{"name":"Ruth and Bruce Rappaport Faculty of Medicine, Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idit","family":"Lavi","sequence":"additional","affiliation":[{"name":"Ruth and Bruce Rappaport Faculty of Medicine, Technion\u2010Israel Institute of Technology  Haifa Israel"},{"name":"Department of Community Medicine and Epidemiology The Lady Davis Carmel Medical Center  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyal","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The Lady Davis Carmel Medical Center  Haifa Israel"},{"name":"Ruth and Bruce Rappaport Faculty of Medicine, Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3005-8863","authenticated-orcid":false,"given":"Yaron","family":"Har\u2010Shai","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The Lady Davis Carmel Medical Center  Haifa Israel"},{"name":"Ruth and Bruce Rappaport Faculty of Medicine, Technion\u2010Israel Institute of Technology  Haifa 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