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Although mid\u2010trimester surgical repair may reduce part of the handicap, an earlier and less invasive approach would further improve the prognosis, possibly minimising maternal and foetal risks. Several studies have proposed an alternative approach to surgical repair by covering the defect with a patch and protecting the exposed neural tissue. Our study aims to elaborate on a waterproof and biodegradable bioactive patch for MMC prenatal foetal repair. We developed a double\u2010layer patch that can provide a waterproof coverage for the spinal cord, with a bioactive side, conducive to cell proliferation, and an antiadhesive side to avoid its attachment to the medulla.<\/jats:p>","DOI":"10.1111\/wrr.13123","type":"journal-article","created":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T03:54:58Z","timestamp":1699934098000},"page":"246-256","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development of a double\u2010layer electrospun patch as a potential prenatal treatment for myelomeningocele"],"prefix":"10.1111","volume":"32","author":[{"given":"K.","family":"Benabdderrahmane","sequence":"first","affiliation":[{"name":"LBPS\/CSPBAT, UMR CNRS 7244, Institut Galil\u00e9e Universit\u00e9 Sorbonne Paris Nord  Villetaneuse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Stirnemann","sequence":"additional","affiliation":[{"name":"Obstetrics and Maternal\u2010Fetal Medicine, H\u00f4pital Necker Enfants Malades, AP\u2010HP  Paris France"},{"name":"EA7328 Institut Imagine &amp; Universit\u00e9 de Paris\u2010Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ramtani","sequence":"additional","affiliation":[{"name":"LBPS\/CSPBAT, UMR CNRS 7244, Institut Galil\u00e9e Universit\u00e9 Sorbonne Paris Nord  Villetaneuse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Falentin\u2010Daudr\u00e9","sequence":"additional","affiliation":[{"name":"LBPS\/CSPBAT, UMR CNRS 7244, Institut Galil\u00e9e Universit\u00e9 Sorbonne Paris Nord  Villetaneuse 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