{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:18:50Z","timestamp":1788445130957,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"am","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020964","name":"Fusion Oriented REsearch for disruptive Science and Technology","doi-asserted-by":"publisher","award":["JPMJFR205H"],"award-info":[{"award-number":["JPMJFR205H"]}],"id":[{"id":"10.13039\/501100020964","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Local low\u2010frequency vibration promotes blood flow and wound healing in hard\u2010to\u2010heal diabetic foot ulcers (DFUs). However, vibration treatment is challenging in patients with DFUs due to wound management difficulties and low adherence. Consequently, developing wearable self\u2010care devices becomes imperative for effective wound healing. This study introduces a wearable vibration dressing and assesses its impact on wound healing in hyperglycemic rats. Low\u2010frequency vibration at 52\u2009Hz was applied to the wound for 40\u2009min\/day in awake rats. Relative wound areas on post\u2010wounding days (PWDs) 4\u20137 were significantly smaller and the wound closure rate was significantly higher in the vibration group than in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05, respectively). The total haemoglobin at baseline and after vibration on post\u2010wounding day 7 was significantly larger in the vibration group than in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). On PWD 7, the thickness of the granulation tissue was significantly higher in the vibration group than in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Moreover, the number of blood vessels at the wound site and vascular endothelial growth factor A protein expression were significantly higher in the vibration group than in the control group (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.05, respectively). The ratio of (CD68<jats:sup>+<\/jats:sup>\/iNOS<jats:sup>+<\/jats:sup>)\/(CD163<jats:sup>+<\/jats:sup>) macrophages in the vibration group was significantly lower than that in the control group (<jats:italic>p\u2009&lt;<\/jats:italic>\u20090.05). These results indicate the potential of wearable vibration dressings as new self\u2010care devices that can promote angiogenesis and blood flow, improve inflammation, and enhance wound healing in DFUs.<\/jats:p>","DOI":"10.1111\/wrr.13129","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T16:04:56Z","timestamp":1699718696000},"page":"816-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of wearable vibration dressings on full\u2010thickness wound healing in a hyperglycemic rat model"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8820-0952","authenticated-orcid":false,"given":"Daijiro","family":"Haba","sequence":"first","affiliation":[{"name":"Department of Gerontological Nursing\/Wound Care Management, Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Global Nursing Research Center, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Ohmiya","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Information Systems, Graduate School of Engineering The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Sekino","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering and Information Systems, Graduate School of Engineering The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3129-3523","authenticated-orcid":false,"given":"Qi","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Gerontological Nursing\/Wound Care Management, Graduate School of Medicine The University of Tokyo  Tokyo 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