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Seventy subjects with varicose veins of lower extremities and venous ulceration were compared with 1164 controls with varicose veins of lower extremities and no history of venous ulceration. Stepwise multivariate logistic regression analysis was used to identify the risk factors for venous ulceration. The steps in developing the diagnostic score model were based on the Framingham Heart study. The area under the receiver operating characteristic curve (AUC) was calculated to assess the diagnostic ability of the diagnostic score model. Multivariate analysis showed that men, overweight, obesity, longer duration varicose veins, deep venous valve insufficiency, low lymphocyte counts, and high fibrinogen content were independently associated with an increased risk of venous ulceration. The AUC for the diagnostic score model was 0.75, which indicated good discriminatory ability. Special attention should be paid to the high\u2010risk group of patients with lower extremity varicose veins. The diagnostic score model might be a useful screening tool for clinicians, policy makers, and patients.<\/jats:p>","DOI":"10.1111\/wrr.13139","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T04:42:35Z","timestamp":1702442555000},"page":"47-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Risk factors for venous ulceration in patients with varicose veins of lower extremities"],"prefix":"10.1111","volume":"32","author":[{"given":"Chaonan","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital  Jinan China"},{"name":"Jinan Clinical Research Center for Tissue Engineering Skin Regeneration and Wound Repair  Jinan China"},{"name":"Center for Big Data Research in Health and Medicine The First Affiliated Hospital of Shandong First 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