{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:44:09Z","timestamp":1790016249693,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T00:00:00Z","timestamp":1703462400000},"content-version":"vor","delay-in-days":54,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetic foot ulcers (DFU) are one of the most frequent and debilitating complications of diabetes. DFU wound healing is a highly complex process, resulting in significant medical, economic\u00a0and social challenges. Therefore, early identification of patients with a high\u2010risk profile would be important to adequate treatment and more successful health outcomes. This study explores risk assessment profiles for DFU healing and healing prognosis, using machine learning predictive approaches and decision tree algorithms. Patients were evaluated at baseline (T0; <jats:italic>N<\/jats:italic>\u2009=\u2009158) and 2\u2009months later (T1; <jats:italic>N<\/jats:italic>\u2009=\u2009108) on sociodemographic, clinical, biochemical and psychological variables. The performance evaluation of the models comprised F1\u2010score, accuracy, precision and recall. Only profiles with F1\u2010score\u2009&gt;0.7 were selected for analysis. According to the two profiles generated for DFU healing, the most important predictive factors were illness representations on T1 IPQ\u2010B (IPQ\u2010B\u2009\u2264\u20099.5 and\u2009&lt;\u200910.5) and the DFU duration (\u2264\u200913\u2009weeks). The two predictive models for DFU healing prognosis suggest that biochemical factors are the best predictors of a favorable healing prognosis, namely IL\u20106, microRNA\u2010146a\u20105p and PECAM\u20101 at T0 and angiopoietin\u20102 at T1. Illness perception at T0 (IPQ\u2010B\u2009\u2264\u200939.5) also emerged as a relevant predictor for healing prognosis. The results emphasize the importance of DFU duration, illness perception and biochemical markers as\u00a0predictors\u00a0of \u00a0healing in chronic DFUs. Future research is needed to confirm and test the obtained predictive models.<\/jats:p>","DOI":"10.1111\/wrr.13141","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T07:33:26Z","timestamp":1702280006000},"page":"793-803","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Healing profiles in patients with a chronic diabetic foot ulcer: An exploratory study with machine learning"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7987-2562","authenticated-orcid":false,"given":"M. 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Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica","family":"Da Silva","sequence":"additional","affiliation":[{"name":"PhD Program in Experimental Biology and Biomedicine (PDBEB) Institute for Interdisciplinary Research  Coimbra Portugal"},{"name":"Center for Neuroscience and Cell Biology (CNC), Center for Innovative Biotechnology and Biomedicine (CIBB) University of Coimbra  Coimbra Portugal"},{"name":"Institute for Interdisciplinary Research University of Coimbra  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Santos","sequence":"additional","affiliation":[{"name":"PhD Program in Experimental Biology and Biomedicine (PDBEB) Institute for Interdisciplinary Research  Coimbra Portugal"},{"name":"Center for Neuroscience and Cell Biology (CNC), Center for Innovative Biotechnology and Biomedicine (CIBB) University of Coimbra  Coimbra Portugal"},{"name":"Institute for Interdisciplinary Research 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