{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:10:22Z","timestamp":1789049422203,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic wounds are a common and costly health issue affecting millions of individuals in the United States, particularly those with underlying conditions such as diabetes, venous insufficiency, and peripheral artery disease. When standard treatments fail, advanced wound care therapies, such as skin substitutes, are often applied. However, the clinical effectiveness, indications, and comparative benefits of these therapies have not been well established. In this study, we report on the usage of both acellular and cellular, single and bilayer, natural and synthetic, dermal, and epidermal skin substitutes in a VA hospital system. We performed a retrospective chart review to understand the ordering and usage patterns of advanced wound therapies for patients with chronic wounds at the VA Northern California Health Care System. We examined types of products being recommended, categories of users recommending the products, indications for orders, and rate of repeated orders. Neuropathic, venous, or pressure ulcers were the main indications for using advanced wound matrices. Only 15.6% of patients for whom the matrices were ordered had supporting laboratory tests. Exactly 34.3% of the ordered matrices were not applied. And the use of wound matrices resulted in increased costs per patient visit of $1018\u2013$3450. Our study sheds light on the usage patterns of these therapies in a VA healthcare facility and highlights the need for more robust evidence\u2010based studies to determine the true benefits, efficacy, and cost\u2010effectiveness of these innovative treatment options.<\/jats:p>","DOI":"10.1111\/wrr.13150","type":"journal-article","created":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T06:29:40Z","timestamp":1705127380000},"page":"118-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Patterns of use of advanced wound matrices in the Veterans Administration clinics"],"prefix":"10.1111","volume":"32","author":[{"given":"Yimeng Lina","family":"Du","sequence":"first","affiliation":[{"name":"University of California Davis, School of Medicine  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallas","family":"Lim","sequence":"additional","affiliation":[{"name":"Dermatology Section VA Northern California Health Care System  Mather California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7813-0858","authenticated-orcid":false,"given":"Rivkah","family":"Isseroff","sequence":"additional","affiliation":[{"name":"Dermatology Section VA Northern California Health Care System  Mather California USA"},{"name":"Department of Dermatology University of California Davis  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Dahle","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California Davis  Sacramento California USA"},{"name":"Podiatry Section VA Northern California Health Care System  Mather California 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