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Traditional Chinese medicine turtle plate powder can treat skin trauma, but its composition is complex and inconvenient to use. Here, we combined cholesterol myristate (S8) with berberine (BBR), with anti\u2010inflammatory and antibacterial effects, as a drug and used hydroxypropyl methylcellulose and polyvinylpyrrolidone K30 as carriers to construct a novel film\u2010forming polymeric solution (S8\u2009+\u2009BBR FFPS), comprehensively study its reparative effect on PU and explore the potential mechanism in rat PU models. The results showed that S8\u2009+\u2009BBR FFPS inhibits excessive inflammatory response, promotes re\u2010epithelialization, and promotes hair follicle growth during the healing process of PU, which may be related to the activation of the Wnt\/\u03b2\u2010catenin signalling pathway by S8\u2009+\u2009BBR FFPS to mediate hair follicle stem cell proliferation and maintain skin homeostasis. Therefore, S8\u2009+\u2009BBR FFPS may be a potential candidate for the treatment of chronic skin injury, and its association with the Wnt\/\u03b2\u2010catenin signalling pathway may provide new ideas to guide the design of biomaterial\u2010based wound dressings for chronic wound repair.<\/jats:p>","DOI":"10.1111\/wrr.13158","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T09:34:26Z","timestamp":1707903266000},"page":"279-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Film\u2010forming polymer solutions containing cholesterol myristate and berberine mediate pressure ulcer repair via the <scp>Wnt\/\u03b2<\/scp>\u2010catenin pathway"],"prefix":"10.1111","volume":"32","author":[{"given":"Yu","family":"Li","sequence":"first","affiliation":[{"name":"School of Nursing, Guangzhou University of Chinese Medicine  Guangzhou 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