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Herein, we report a case of self\u2010improving DEB with <jats:italic>COL7A1<\/jats:italic> p.Gly2025Asp variant. The diagnosis was made through histopathological, electron microscopic examination, and genetic testing. The same variant is also noted on his father, who presents with dystrophic toenails without any blisters. This study highlights that idiopathic nail dystrophy could be linked to congenital or hereditary disease. Furthermore, we conducted a review of the literature on the characteristics of reported cases of self\u2010improving DEB with a personal or family history of nail dystrophy. The results supported our findings that nail dystrophy may be the sole manifestation in some family members. We suggest that individuals suffering from idiopathic nail dystrophy may seek genetic counselling when planning pregnancy to early evaluate the potential risk of hereditary diseases.<\/jats:p>","DOI":"10.1111\/wrr.13159","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T10:49:30Z","timestamp":1709117370000},"page":"511-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Self\u2010improving dystrophic epidermolysis bullosa with a novel heterozygous missense variant in the <scp><i>COL7A1<\/i><\/scp> gene in a Taiwanese family"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8471-374X","authenticated-orcid":false,"given":"Yi\u2010Chia","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of General Medicine Kaohsiung Chang Gung Memorial Hospital  Kaohsiung 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