{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:06:27Z","timestamp":1793253987828,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T00:00:00Z","timestamp":1710633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diabetic foot ulcers are a common and severe complication of diabetes mellitus, and a risk factor for amputation. Because of the vessel insufficiency in diabetic foot ulcers (DFU), vascular endothelial growth factor (VEGF) that simulates angiogenesis is of interest to promote wound healing. This systematic review evaluates the last 16\u2009years of in\u2010vivo studies with VEGF stimulation as a treatment for DFU, developed based on the last published systematic article. A total of 961 articles were identified through databases in two phases. 947 articles were excluded by exclusion criteria, and four articles met our inclusion criteria and were included. The effects of VEGF on wound healing were analysed in all four studies. In three studies, the VEGF\u2010treated wounds showed statistically faster healing than those not treated with VEGF. In one study, the VEGF\u2010treated wounds revealed a positive trend toward faster healing. Furthermore, all four studies were in favor of using VEGF, but concluded that further research is needed. These studies showed a positive trend towards faster healing and was safe when using VEGF topically on humans. Furthermore, viral particles of VEGF seem to have a systematic effect when a dose exceeding 5.0\u2009\u00d7\u200910<jats:sup>9<\/jats:sup> vp pr wound. Future research in using VEGF on DFU should focus on VEGF's relevant dosage, release rate, and specific mechanism. This review inspires further research, and a consistent study design is prerequisite such that results are more homogenic and comparable. Much effort is needed to translate the results into our clinical practice.<\/jats:p>","DOI":"10.1111\/wrr.13171","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T06:35:16Z","timestamp":1710743716000},"page":"384-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The effect of <scp>VEGF<\/scp> stimulation in diabetic foot ulcers: A systematic review"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2143-5121","authenticated-orcid":false,"given":"Frederik S.","family":"Bang","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5670-095X","authenticated-orcid":false,"given":"Veronica","family":"Leeberg","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology Odense University Hospital, Institute of Clinical Research, University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-8079","authenticated-orcid":false,"given":"Ming","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology CORI\u2014Centre for Orthopaedic Research and Innovation, Slagelse Hospital  Slagelse Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris H.","family":"Dreyer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology Odense University Hospital, Institute of Clinical Research, University of Southern Denmark  Odense Denmark"},{"name":"Department of Orthopaedic Surgery and Traumatology CORI\u2014Centre for Orthopaedic Research and Innovation, Slagelse Hospital  Slagelse Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,17]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"BoykoEJ MaglianoDJ KaruangaS et al.IDF Diabetes Atlas. 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