{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:16:24Z","timestamp":1793794584066,"version":"4.6.1"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to evaluate the diagnostic characteristics of biomarker for diabetic foot osteomyelitis (DFO). We searched PubMed, Scopus, Embase and Medline for studies who report serological markers and DFO before December 2022. Studies must include at least one of the following diagnostic parameters for biomarkers: area under the curve, sensitivities, specificities, positive predictive value, negative predictive value. Two authors evaluated quality using the Quality Assessment of Diagnostic Accuracy Studies tool. We included 19 papers. In this systematic review, there were 2854 subjects with 2134 (74.8%) of those patients being included in the meta\u2010analysis. The most common biomarkers were erythrocyte sedimentation rate (ESR), C\u2010reactive protein (CRP) and procalcitonin (PCT). A meta\u2010analysis was then performed where data were evaluated with Forrest plots and receiver operating characteristic curves. The pooled sensitivity and specificity were 0.72 and 0.75 for PCT, 0.72 and 0.76 for CRP and 0.70 and 0.77 for ESR. Pooled area under the curves for ESR, CRP and PCT were 0.83, 0.77 and 0.71, respectfully. Average diagnostic odds ratios were 16.1 (range 3.6\u201355.4), 14.3 (range 2.7\u201348.7) and 6.7 (range 3.6\u201310.4) for ESR, CRP and PCT, respectfully. None of the biomarkers we evaluated could be rated as \u2018outstanding\u2019 to diagnose osteomyelitis. Based on the areas under the curve, ESR is an \u2018excellent\u2019 biomarker to detect osteomyelitis, and CRP and PCT are \u2018acceptable\u2019 biomarkers to diagnose osteomyelitis. Diagnostic odds ratios indicate that ESR, CRP and PCT are \u2018good\u2019 or \u2018very good\u2019 tools to identify osteomyelitis.<\/jats:p>","DOI":"10.1111\/wrr.13174","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T06:34:01Z","timestamp":1712126041000},"page":"366-376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Update of biomarkers to diagnose diabetic foot osteomyelitis: A meta\u2010analysis and systematic review"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9179-0658","authenticated-orcid":false,"given":"Elizabeth A.","family":"Ansert","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur N.","family":"Tarricone","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Department of Orthopedic Surgery University of Texas Health Science Center  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8598-8350","authenticated-orcid":false,"given":"Tyler L.","family":"Coye","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Crisologo","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2688-066X","authenticated-orcid":false,"given":"David","family":"Truong","sequence":"additional","affiliation":[{"name":"Surgical Service, Podiatry Section, Veteran Affairs North Texas Health Care System  Dallas Texas USA"},{"name":"Department of Orthopedic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-0909","authenticated-orcid":false,"given":"Mehmet A.","family":"Suludere","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A.","family":"Lavery","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas 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