{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:50:41Z","timestamp":1781866241079,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An argon\u2010based low\u2010temperature plasma jet (LTPJ) was used to treat chronically infected wounds in <jats:italic>Staphylococcus aureus<\/jats:italic>\u2010laden mice. Based on physicochemical property analysis and in vitro antibacterial experiments, the effects of plasma parameters on the reactive nitrogen and oxygen species (RNOS) content and antibacterial capacity were determined, and the optimal treatment parameters were determined to be 4 standard litre per minute and 35\u2009W. Additionally, the plasma\u2010treated activation solution had a bactericidal effect. Although RNOS are related to the antimicrobial effect of plasma, excess RNOS may be detrimental to wound remodelling. In vivo studies demonstrated that medium\u2010dose LTPJ promoted MMP\u20109 expression and inhibited bacterial growth during the early stages of healing. Moreover, LTPJ increased collagen deposition, reduced inflammation, and restored blood vessel density and TGF\u2010\u03b2 levels to normal in the later stages of wound healing. Therefore, when treating chronically infected wounds with LTPJ, selecting the medium dose of plasma is more advantageous for wound recovery. Overall, our study demonstrated that low\u2010temperature plasma jets may be a potential tool for the treatment of chronically infected wounds.<\/jats:p>","DOI":"10.1111\/wrr.13178","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T08:49:58Z","timestamp":1712825398000},"page":"407-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Low\u2010temperature plasma jet suppresses bacterial colonisation and affects wound healing through reactive species"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8080-601X","authenticated-orcid":false,"given":"Yang","family":"Ge","sequence":"first","affiliation":[{"name":"The CAS Key Laboratory of Bio\u2010Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences  Suzhou Jiangsu 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