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Chronic wounds pose significant healthcare challenges, often leading to severe complications for millions of people in the United States, and disproportionally affect African American, Hispanic, and Native American individuals. Social determinants of health, including economic stability, access to healthcare, education, and environmental conditions, likely influence stress, weathering, and nutrition, collectively shaping vulnerability to chronic diseases, such as obesity and DM, and an elevated risk of chronic wounds and subsequent lower extremity amputations. Here, we review these issues and discuss the urgent need for further research focusing on understanding the mechanisms underlying racial\/ethnic disparities in chronic wounds, particularly social deprivation, weathering, and nutrition, to inform interventions to address these disparities.<\/jats:p>","DOI":"10.1111\/wrr.13200","type":"journal-article","created":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T07:11:06Z","timestamp":1719645066000},"page":"770-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Racial\/ethnic disparities in chronic wounds: Perspectives on linking upstream factors to health outcomes"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6838-2621","authenticated-orcid":false,"given":"Jacqueline","family":"Cavalcante\u2010Silva","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Nutrition University of Illinois at Chicago  Chicago Illinois USA"},{"name":"Center for Wound Healing and Tissue Regeneration University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giamila","family":"Fantuzzi","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Nutrition University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Minshall","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Illinois at Chicago  Chicago Illinois USA"},{"name":"Department of Pharmacology University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Podiatric Medicine &amp; Surgery, Center for Stem Cell and Regenerative Medicine Rosalind Franklin University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa M.","family":"Oddo","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Nutrition University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Nutrition University of Illinois at Chicago  Chicago Illinois USA"},{"name":"Center for Wound Healing and Tissue Regeneration University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,29]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"National Center for Chronic Disease Prevention and Health Promotion.National Diabetes Statistics Report. 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