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If left untreated, DFU can lead to amputation or even endanger the patient's life. Single\u2010cell RNA sequencing (scRNA\u2010seq) is a technique used to identify and characterise transcriptional subpopulations at the single\u2010cell level. It provides insight into cellular function and the molecular drivers of disease. The objective of this paper is to examine the subpopulations, genes and molecules of cells associated with chronic wounds of diabetic foot by using scRNA\u2010seq. The paper aims to explore the wound\u2010healing mechanism of DFU from three aspects: inflammation, angiogenesis and extracellular matrix remodelling. The goal is to gain a better understanding of the mechanism of DFU wound healing and identify possible DFU therapeutic targets, providing new insights for the application of DFU personalised therapy.<\/jats:p>","DOI":"10.1111\/wrr.13218","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T13:55:15Z","timestamp":1726149315000},"page":"880-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Single\u2010cell <scp>RNA<\/scp>\u2010seq in diabetic foot ulcer wound healing"],"prefix":"10.1111","volume":"32","author":[{"given":"Yan","family":"Dong","sequence":"first","affiliation":[{"name":"Medical School Nantong University  Nantong China"},{"name":"Department of Burn and Plastic Surgery Affiliated Hospital 2 of Nantong University, The First People's Hospital of Nantong  Nantong 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