{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T06:40:13Z","timestamp":1732344013915,"version":"3.28.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To gain a clearer understanding of the relationship between venous leg ulcers (VLUs) and knee osteoarthritis (KOA), we performed a two\u2010sample, bidirectional Mendelian randomization (MR) analysis in this study. The present MR was carried out using summary data from publicly available genome\u2010wide association studies. After filtering single\u2010nucleotide polymorphism (SNP), we applied a variety of MR methods including inverse variance weighted (IVW), MR egger, weighted mode, and weighted median. IVW analysis revealed that the genetic association between VLUs and KOA was not significant (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.017; SE 0.039; <jats:italic>p<\/jats:italic>\u2009=\u20090.658). In agreement with the IVW analysis, the findings of the weighted median estimator (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.017; SE 0.052, <jats:italic>p<\/jats:italic>\u2009=\u20090.751), MR egger (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.057; SE 0.084; <jats:italic>p<\/jats:italic>\u2009=\u20090.513), and weighted mode (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.060; SE 0.078; <jats:italic>p<\/jats:italic>\u2009=\u20090.456) indicated the absence of a significant genetic association between VLUs and KOA. Furthermore, reverse causality analysis suggested a lack of genetic relationship between KOA and VLUs. In conclusion, the present MR study does not suggest a causal relationship or reverse causal relationship between VLUs and KOA.<\/jats:p>","DOI":"10.1111\/wrr.13229","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T06:38:38Z","timestamp":1729751918000},"page":"895-903","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between venous leg ulcers and knee osteoarthritis: A Mendelian randomization study"],"prefix":"10.1111","volume":"32","author":[{"given":"Deyi","family":"Pan","sequence":"first","affiliation":[{"name":"Department of emergency The Second Affiliated Hospital of Fujian Medical University  Quanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runqiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Second Affiliated Hospital of Fujian Medical University  Quanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuemei","family":"Chen","sequence":"additional","affiliation":[{"name":"Thyroid gland and mammary gland surgery department The Second Affiliated Hospital of Fujian Medical University  Quanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shixiong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of emergency The Second Affiliated Hospital of Fujian Medical University  Quanzhou 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