{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:26:48Z","timestamp":1787066808351,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["Translational Research Award 7\u201014\u2010TS\u201020"],"award-info":[{"award-number":["Translational Research Award 7\u201014\u2010TS\u201020"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2025,1]]},"abstract":"Abstract<\/jats:title>\n \n Our objective was to assess the incidence, risk factors and clinical outcomes of dehiscence after foot surgery in diabetic patients. We used pooled patient\u2010level data from two randomised clinical trials with 240 diabetic patients who required foot surgery for infections. Most patients (\n n<\/jats:italic>\n \u2009=\u2009180, 75.0%) had surgical wound closure. We defined dehisced surgical wounds (DSW) when the surgical site was not completely epithelialized with no drainage after sutures\/staples were removed with a 2\u2010week validation of healing. We evaluated the time to heal, re\u2010infection, re\u2010ulceration, hospital admissions and amputations. Moderate and severe infection was based on criteria of the International Working Group on the Diabetic Foot. We used\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n and\n t<\/jats:italic>\n \u2010test and Mann\u2013Whitney\n U<\/jats:italic>\n for comparison of clinical events, with\n \u03b1<\/jats:italic>\n of <0.05. DSW occurred in 137 (76.1%) patients. DSW patients were more likely to have hypertension (62.8% vs. 81.8%,\n p<\/jats:italic>\n \u2009=\u20090.01), high ESR (59.1\u2009\u00b1\u200937.9 vs. 75.9\u2009\u00b1\u200937.6,\n p<\/jats:italic>\n \u2009=\u20090.01), low toe brachial indices (0.8\u2009\u00b1\u20090.2) (0.7\u2009\u00b1\u20090.2,\n p<\/jats:italic>\n \u2009=\u20090.005), toe brachial indices <0.6 (16.7% vs. 40.9%,\n p<\/jats:italic>\n \u2009=\u20090.008), and low skin perfusion pressure measurements (dorsal medial 71.0\u2009\u00b1\u200929.4 vs. 59.3\u2009\u00b1\u200923.3,\n p<\/jats:italic>\n \u2009=\u20090.01, and plantar medial 81.8\u2009\u00b1\u200924.9 vs. 72.2\u2009\u00b1\u200920.4,\n p<\/jats:italic>\n \u2009=\u20090.02). During 12\u2010month follow\u2010up, DSW patients were 12.9 times more likely to have re\u2010infection (0% vs. 12.4%,\n p<\/jats:italic>\n \u2009=\u20090.02) and 6.8 times more likely to require amputation (2.3% vs. 13.9%,\n p<\/jats:italic>\n \u2009=\u20090.04). The median healing time (28, 22.5\u201335.0 vs. 114.0, 69.0; 365,\n p<\/jats:italic>\n \u2009=\u20090.001), and median length of hospitalisation were longer in DSW patients (12.0, 9.01\u20139.0 vs. 15.0, 11.0\u201324.0,\n p<\/jats:italic>\n \u2009=\u20090.04). There was a high incidence of DSW, associated with poor clinical outcomes.\n <\/jats:p>","DOI":"10.1111\/wrr.13235","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:35:31Z","timestamp":1734309331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The infected diabetic foot: Incidence and risk factors for dehiscence after surgery for diabetic foot infections"],"prefix":"10.1111","volume":"33","author":[{"given":"Lawrence A.","family":"Lavery","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario C.","family":"Reyes","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijan","family":"Najafi","sequence":"additional","affiliation":[{"name":"Department of Surgery Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler L.","family":"Coye","sequence":"additional","affiliation":[{"name":"Department of Surgery Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayer","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Surgery Baylor College of Medicine Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Siah","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur N.","family":"Tarricone","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1071100716688073"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2020.02.044"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12741"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0741\u20105214(99)70078\u20109"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10016\u2010005\u20107973\u20103"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad527"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7547\/20\u2010217"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3280"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13143"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/15347346231191588"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13101"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3701"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.13235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T01:40:34Z","timestamp":1743730834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.13235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,15]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/wrr.13235"],"URL":"https:\/\/doi.org\/10.1111\/wrr.13235","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,15]]},"assertion":[{"value":"2024-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e13235"}}