{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:51:35Z","timestamp":1792929095422,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This meta\u2010analysis aimed to systematically assess and synthesise healing rates within a 12\u2010 to 24\u2010week treatment\u00a0period among patients with diabetic foot ulcers receiving standard\u2010of\u2010care interventions in randomised controlled trials. This meta\u2010analysis included 32 randomised controlled trials conducted between 1996 and 2023, with sample sizes ranging from 9 to 169 patients. A random\u2010effects model was applied to estimate pooled healing and infection rates. Heterogeneity was quantified using the\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    statistic, and publication bias was assessed using Egger's test. The results\u00a0revealed a pooled healing rate of 33.15% with a 95% confidence interval (CI) of 31.18%\u201335.11% and an average healing time of approximately 50.14\u2009days (standard deviation: 31.10\u2009days). The infection proportion was determined to be 17.4% (95% CI: 12.2%\u201322.5%). Subgroup analysis indicated marginally higher healing rates in the \u2018Saline Gauze\u2019 group compared to the \u2018Alginate\u2019 group, although the latter exhibited a reduced infection proportion. Sensitivity analysis affirmed the robustness of these findings whereas Egger's test suggested the presence of potential publication bias concerning the healing outcomes. The standard\u2010of\u2010care interventions for diabetic foot ulcers demonstrate limited effectiveness, with only about one\u2010third of patients achieving wound closure. The significant heterogeneity and publication bias observed necessitate a cautious interpretation of these results. The findings highlight the need for advanced wound care strategies and personalised treatment plans to improve outcomes in diabetic foot ulcers management. Future research should focus on conducting high\u2010quality, well\u2010reported randomised controlled trials to better understand effective treatments for DFUs.\n                  <\/jats:p>","DOI":"10.1111\/wrr.13237","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T01:29:08Z","timestamp":1733794148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Healing of diabetic neuropathic foot ulcers receiving standard treatment in randomised controlled trials: A random effects meta\u2010analysis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8598-8350","authenticated-orcid":false,"given":"Tyler L.","family":"Coye","sequence":"first","affiliation":[{"name":"Michael DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4419-1761","authenticated-orcid":false,"given":"Miguel","family":"Bargas Ochoa","sequence":"additional","affiliation":[{"name":"Michael DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3663-6882","authenticated-orcid":false,"given":"Alejandro","family":"Zulbaran\u2010Rojas","sequence":"additional","affiliation":[{"name":"Michael DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9292-2031","authenticated-orcid":false,"given":"Bernardo","family":"Martinez Leal","sequence":"additional","affiliation":[{"name":"Michael DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abderrahman","family":"Ouattas","sequence":"additional","affiliation":[{"name":"Michael DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5311-6283","authenticated-orcid":false,"given":"Arthur","family":"Tarricone","sequence":"additional","affiliation":[{"name":"Department of Orthopedics University of Texas Health Sciences  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6404-4414","authenticated-orcid":false,"given":"Jayer","family":"Chung","sequence":"additional","affiliation":[{"name":"Michael DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0320-8101","authenticated-orcid":false,"given":"Bijan","family":"Najafi","sequence":"additional","affiliation":[{"name":"Michael DeBakey Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-9952","authenticated-orcid":false,"given":"Lawrence A.","family":"Lavery","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0141076816688346"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2014.04.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3402\/dfa.v6.29629"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.5.692"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470870168.ch6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.4.350"},{"key":"e_1_2_8_9_1","unstructured":"U.S. Food and Drug Administration.Summary of safety and effectiveness data. 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