{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:48Z","timestamp":1787016048072,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["7\u201014\u2010TS\u201020"],"award-info":[{"award-number":["7\u201014\u2010TS\u201020"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018599","name":"Cardinal Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018599","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Our objective was to evaluate risk factors for re\u2010infection in patients after treatment for diabetic foot osteomyelitis (OM). We used pooled patient level data from two RTCs that evaluated patients with diabetic foot infections. We evaluated 171 patients with OM. OM was confirmed with bone culture or histopathology. Data from the 12\u2010month follow\u2010up were used to determine clinical outcomes. Re\u2010infection occurred in 47 (27.5%) patients. Risk factors for re\u2010infection were Toe Brachial Index &lt;0.40 (25.7% vs. 9.8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02), skin perfusion pressure &lt;40\u2009mmHg (6.3% vs. 5.9%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04), wound healing (55.3% vs. 75.0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01), time to heal (156.0, 69.5\u2013365 vs. 91.5, 38.8\u2013365,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), and history of MI (14.9% vs. 3.2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.005). During 12\u2010month follow\u2010up, patients with re\u2010infections were 198.8 times more likely to require a foot related hospitalisation (81.8% vs. 0.0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), 10.4 times more likely have an all\u2010cause hospitalisation (70.2% vs. 18.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) and 9.4 times more likely to need an amputation (36.2% vs. 5.6%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Patients with re\u2010infection had a significantly longer median length of hospitalisation (20.0, 13.5\u201334.5 vs. 14.0, 10.0\u201322.0,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003) and median length of antibiotic duration (55.0, 35.0\u201387.0 vs. 46.0, 22.8\u201368.0,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03). Patients with re\u2010infection are less likely to heal and have more foot\u2010related hospitalizations and amputations.\n                  <\/jats:p>","DOI":"10.1111\/wrr.13246","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T06:09:33Z","timestamp":1737439773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The infected diabetic foot: Risk factors for re\u2010infection after treatment for diabetic foot osteomyelitis"],"prefix":"10.1111","volume":"33","author":[{"given":"Lawrence A.","family":"Lavery","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Department of Orthopedic Surgery University of Texas Health Science Center San Antonio  Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario C.","family":"Reyes","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijan","family":"Najafi","sequence":"additional","affiliation":[{"name":"Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler L.","family":"Coye","sequence":"additional","affiliation":[{"name":"Department of Surgery Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Sideman","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Texas Health Science Center San Antonio  Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Siah","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur N.","family":"Tarricone","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery University of Texas Health Science Center San Antonio  Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1071100716664364"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548.2013.765589"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100029\u20101212006"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi1970.61.619"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12741"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2020.02.044"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz489"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3280"},{"issue":"9","key":"e_1_2_11_10_1","first-page":"488","article-title":"Vacuum sealing as treatment of soft tissue damage in open 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