{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:07:41Z","timestamp":1790111261848,"version":"4.0.1"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["10070022010003"],"award-info":[{"award-number":["10070022010003"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Deep dermal and full\u2010thickness burns often result in scar sequelae such as contractures, hypertrophy, pain and itching following split\u2010thickness skin grafting. Dermal substitutes are currently employed alongside split\u2010thickness skin grafting to enhance clinical outcomes, though their indications remain a subject of ongoing debate. This systematic review aims to clarify the indications for the application of dermal substitutes in burn patients, in both acute and reconstructive settings. A comprehensive search across various databases was conducted. Studies (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009190) assessing the indications and outcomes of dermal substitutes in acute burn patients and those requiring reconstructive surgery were included. Data extraction included the applied dermal substitute, age, total body surface area, wound depth, burn aetiology, anatomical site and exclusion criteria. The indications were derived from predetermined indications, i.e. inclusion and exclusion criteria and patient characteristics. The depth of the wound emerged as the primary indication for dermal substitute use. A one\u2010stage approach is recommended for deep dermal to full\u2010thickness wounds larger than 10\u2009cm\n                    <jats:sup>2<\/jats:sup>\n                    , while a two\u2010stage approach is advised for wounds of this depth with limited donor sites or exposed bone or tendon. No definitive age or burn\/scar location thresholds were identified, and careful consideration is advised for electrical and chemical burns. Contraindications include wound infections and allergies to matrix components. Limited data exist on use in patients with diabetes mellitus, chronic vascular disease, or immunocompromised status. This is the first review to address the indications for dermal substitutes in burn patients, providing valuable insights for the development of international evidence\u2010based treatment guidelines.\n                  <\/jats:p>","DOI":"10.1111\/wrr.13248","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T06:44:21Z","timestamp":1735281861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Indications for the use of dermal substitutes in patients with acute burns and in reconstructive surgery after burns: A systematic review"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0471-537X","authenticated-orcid":false,"given":"Anna S.","family":"van den Bosch","sequence":"first","affiliation":[{"name":"Alliance of Dutch Burn Care (ADBC), Burn Centre Red Cross Hospital  Beverwijk The Netherlands"},{"name":"Department of Plastic, Reconstructive &amp; Hand Surgery Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Movement Sciences, Tissue Function and Regeneration Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin A. F.","family":"Verwilligen","sequence":"additional","affiliation":[{"name":"Alliance of Dutch Burn Care (ADBC), Burn Centre Red Cross Hospital  Beverwijk The Netherlands"},{"name":"Department of Plastic, Reconstructive &amp; Hand Surgery Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Movement Sciences, Tissue Function and Regeneration Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Pijpe","sequence":"additional","affiliation":[{"name":"Alliance of Dutch Burn Care (ADBC), Burn Centre Red Cross Hospital  Beverwijk The Netherlands"},{"name":"Department of Plastic, Reconstructive &amp; Hand Surgery Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Movement Sciences, Tissue Function and Regeneration Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lex B.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Alliance of Dutch Burn Care (ADBC), Burn Centre Red Cross Hospital  Beverwijk The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis H.","family":"van der Vlies","sequence":"additional","affiliation":[{"name":"Alliance of Dutch Burn Care (ADBC), Burn Centre Maasstad Hospital  Rotterdam The Netherlands"},{"name":"Department of Trauma and Burn Surgery Maasstad Hospital  Rotterdam The Netherlands"},{"name":"Trauma Research Unit, Department of Surgery, Erasmus MC University Medical Centre  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merit E.","family":"van Eck","sequence":"additional","affiliation":[{"name":"Alliance of Dutch Burn Care (ADBC), Burn Centre Martini Hospital  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George L.","family":"Burchell","sequence":"additional","affiliation":[{"name":"Medical Library Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul P. M.","family":"van Zuijlen","sequence":"additional","affiliation":[{"name":"Alliance of Dutch Burn Care (ADBC), Burn Centre Red Cross Hospital  Beverwijk The Netherlands"},{"name":"Department of Plastic, Reconstructive &amp; Hand Surgery Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Movement Sciences, Tissue Function and Regeneration Amsterdam UMC  Amsterdam The Netherlands"},{"name":"Pediatric Surgical Centre, Emma Children's Hospital Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8843-1080","authenticated-orcid":false,"given":"Esther","family":"Middelkoop","sequence":"additional","affiliation":[{"name":"Alliance of Dutch Burn Care (ADBC), Burn Centre Red Cross Hospital  Beverwijk The Netherlands"},{"name":"Department of Plastic, Reconstructive &amp; Hand Surgery Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Movement Sciences, Tissue Function and Regeneration Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the National Burn Care, Education & Research Group, The Netherlands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,27]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organization.Fact sheet burns 2023.2023. 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