{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T07:13:18Z","timestamp":1763190798403,"version":"3.45.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic wounds (CW) are a major public health problem. Acellular fish skin grafts (AFSG) are increasingly used in advanced wound care, but data on their effectiveness and costs in real\u2010world settings are scarce. We therefore retrospectively analysed the wound surface area (WSA), pain scores, and AFSG\u2010related costs in patients with CW over a 12\u2010week follow\u2010up period. In this single\u2010centre observational study, we analysed two datasets of 34 (full dataset) and 22 (WSA\u2010dataset) CW patients treated with AFSG in a university hospital. Of 34 AFSG\u2010treated patients (mean age 75.9\u2009\u00b1\u200911.4\u2009years, 44.0% females) with 50 CW of various aetiologies (median ulcer duration 32\u2009weeks), 66.6% experienced pain improvement at 12\u2009weeks. Of 22 patients, 19 (86.4%) showed a mean reduction in WSA of \u221260.7%\u2009\u00b1\u2009143.8% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0025); 36.4% of CW were healed. AFSG\u2010related costs were 1232.3 EUR\/patient and 130.4 EUR\/reduced cm\n                    <jats:sup>2<\/jats:sup>\n                    (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200922), which was 6.5 times more cost\u2010effective compared to previous study results using living cellular skin substitutes. During 12\u2009weeks of follow\u2010up in a real\u2010world setting, AFSG resulted in reduced WSA in most patients, improved pain in two\u2010thirds, and healed CW in one\u2010third. AFSG may be more cost\u2010effective than other products, but prospective head\u2010to\u2010head comparisons are needed.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70019","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T05:55:07Z","timestamp":1745906107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010world outcomes of acellular fish skin grafts for chronic wounds: A retrospective analysis of effectiveness and costs"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5521-3642","authenticated-orcid":false,"given":"Pavlo","family":"Dinter","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander A.","family":"Navarini","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon M.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2018.10.005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010039411"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102133.2003.05222.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201300071"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13032"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(03)00306\u20104"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.08.068"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742\u2010481X.2012.01097.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102702.2009.03151.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2013.22.9.501"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2015.0635"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.17992\/lbl.2015.12.54"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12761"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.52198\/22.STI.40.WH1494"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.25270\/wnds\/2021.169177"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.25270\/wnds\/2022.e34e36"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbcr\/irz205"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1700063"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.12687\/phleb2305\u20102\u20102016"},{"issue":"4","key":"e_1_2_11_21_1","first-page":"112","article-title":"A prospective, postmarket, compassionate clinical evaluation of a novel acellular fish\u2010skin graft which contains omega\u20103 fatty acids for the closure of hard\u2010to\u2010heal lower extremity chronic ulcers","volume":"28","author":"Yang CK","year":"2016","journal-title":"Wounds Compend Clin Res Pract"},{"issue":"10","key":"e_1_2_11_22_1","first-page":"283","article-title":"Cost effectiveness of fish skin grafts versus standard of care on wound healing of chronic diabetic foot ulcers: a retrospective comparative cohort study","volume":"32","author":"Winters C","year":"2020","journal-title":"Wounds Compend Clin Res Pract"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.25270\/wnds\/22094"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58121775"},{"issue":"10","key":"e_1_2_11_25_1","first-page":"262","article-title":"Acellular fish skin graft use for diabetic lower extremity wound healing: a retrospective study of 58 ulcerations and a 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