{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:55:30Z","timestamp":1789239330740,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:00:00Z","timestamp":1743811200000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012821"],"award-info":[{"award-number":["2024A1515012821"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aims to systematically evaluate the effect of low\u2010level laser therapy on grade I\u2013II diabetic foot ulcers. We conducted a systematic search of the PubMed, Embase, Web of Science, EBSCO, Cochrane, ClinicalKey, Ovid Medline, Sinomed, CNKI, and WANFANG databases for studies assessing the efficacy of low\u2010level laser therapy for diabetic foot ulcers, with a cutoff date of 15 September 2024. Two researchers independently selected relevant studies and extracted data, utilising RevMan 5.4 software to perform a meta\u2010analysis. A total of 11 studies involving 657 participants with grade I\u2010II diabetic foot ulcers were included. In patients with grade I\u2010II diabetic foot ulcers, low\u2010level laser therapy significantly increased the complete healing rate (RR\u2009=\u20094.97, 95% CI: 2.65\u20139.32, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001), the wound shrinkage area (MD\u2009=\u20097.76, 95% CI: 6.51\u20139.0, <jats:italic>p<\/jats:italic>\u2009&lt;0.00001), and the wound bacterial clearance rate (RR\u2009=\u20093.72, 95% CI: 2.16\u20136.39, <jats:italic>p<\/jats:italic>\u2009&lt;0.00001) compared to the control group, while also reducing the infection rate (RR\u2009=\u20090.11, 95% CI: 0.01\u20130.8, <jats:italic>p<\/jats:italic>\u2009&lt;0.03). Low\u2010level laser therapy is an effective adjuvant therapy that accelerates wound healing in patients with grade I\u2013II diabetic foot ulcers. However, further research is necessary to validate its effects on wound area reduction rate and healing time.<\/jats:p>","DOI":"10.1111\/wrr.70021","type":"journal-article","created":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T02:27:13Z","timestamp":1743906433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Intervention effects of low\u2010level laser therapy (<scp>LLLT<\/scp>) on grade I\u2013<scp>II<\/scp> ulcers in diabetic foot patients: A meta\u2010analysis"],"prefix":"10.1111","volume":"33","author":[{"given":"Binxiong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Burn and Plastic Surgery Shenzhen Longhua District Central Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhe","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery Shenzhen Longhua District Central Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyun","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery Shenzhen Longhua District Central Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery Shenzhen Longhua District Central Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery Shenzhen Longhua District Central Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Burn and Plastic Surgery Shenzhen Longhua District Central Hospital  Shenzhen Guangdong 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