{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:22:15Z","timestamp":1787167335934,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Split\u2010thickness skin graft donor site wounds present significant challenges in pain management and healing optimization. This intra\u2010individual comparative study evaluated the efficacy and safety of a novel topical solution containing tranexamic acid, adrenaline and bupivacaine versus standard paraffin\u2010chlorhexidine dressings, with side allocation determined by computer randomisation after graft harvesting. Twelve patients received standardised solution application on one donor site and standard treatment on the contralateral site, with each side's dressing changes performed according to protocol. The treatment group demonstrated significantly lower mean pain scores across all time intervals (1.1 vs. 5.3 at 24\u2009h,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Mean epithelialization rates at Days 10\u201314 were higher in the treatment group (97.1% vs. 94.8%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), with faster time to complete healing (median 12 vs. 16\u2009days,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002). No significant hemodynamic changes occurred following solution application, with only one case of transient tachycardia reported. Vancouver Scar Scale scores at eight weeks showed a trend favouring the treatment (3.8 vs. 4.2,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.15), although this difference was not statistically significant. No infections were observed in either group. These findings suggest that this novel topical solution with transparent film dressing effectively reduces pain and accelerates healing in donor site wounds without compromising safety, providing a promising new option for managing these challenging surgical wounds.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70060","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T04:55:06Z","timestamp":1751432106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Topical Tranexamic Acid, Adrenaline and Bupivacaine Solution for Pain Management and Healing in Split\u2010Thickness Skin Graft Donor Sites: An Open\u2010Label Interventional Study With Randomised Side Allocation"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1359-646X","authenticated-orcid":false,"given":"Pattana","family":"Ongkasuwan","sequence":"first","affiliation":[{"name":"Plastic and Reconstructive Surgery, General Surgery Department Nakornping Hospital  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001928"},{"key":"e_1_2_10_3_1","first-page":"43","article-title":"Split\u2010Thickness Skin Graft Donor Site Care: A Quantitative Synthesis of the Research","volume":"31","author":"Rakel B. A.","year":"2018","journal-title":"Applied Nursing Research"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"237","article-title":"The Use of Urgotul in the Treatment of Partial Thickness Burns and Split\u2010Thickness Skin Graft Donor Sites: A Prospective Control Study","volume":"16","author":"Tan P. W.","year":"2019","journal-title":"International Wound Journal"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2009.05.017"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001615"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2007.08.011"},{"issue":"4","key":"e_1_2_10_8_1","first-page":"460","article-title":"The Influence of Moisture in Wound Healing: A Review","volume":"18","author":"Holmskov K.","year":"2021","journal-title":"International Wound Journal"},{"issue":"8","key":"e_1_2_10_9_1","first-page":"1764","article-title":"Topical Application of Local Anesthetics for Split\u2010Thickness Skin Graft Donor Site Pain Management: A Systematic Review and Meta\u2010Analysis","volume":"74","author":"Koo Y.","year":"2021","journal-title":"Journal of Plastic, Reconstructive & Aesthetic Surgery"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41038-016-0036-x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9193"},{"issue":"11","key":"e_1_2_10_12_1","article-title":"Bupivacaine Extended\u2010Release Liposome Injection for Prolonged Postsurgical Analgesia in Plastic Surgery: A Review","volume":"7","author":"Borkar N. B.","year":"2019","journal-title":"Plastic and Reconstructive Surgery \u2010 Global Open"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00067.2017"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-021-02512-4"},{"issue":"3","key":"e_1_2_10_15_1","article-title":"Pain Management in Plastic Surgery: Current Practice and Emerging Techniques","volume":"9","author":"Safian R. R.","year":"2021","journal-title":"Plastic and Reconstructive Surgery \u2010 Global Open"},{"key":"e_1_2_10_16_1","article-title":"A Review of Scar Scales and Scar Measuring Devices","volume":"10","author":"Fearmonti R.","year":"2010","journal-title":"Eplasty"},{"issue":"3","key":"e_1_2_10_17_1","first-page":"509","article-title":"Absorption and Tissue Distribution of Tranexamic Acid After Topical Application","volume":"25","author":"Yamamoto H.","year":"2020","journal-title":"Journal of Orthopaedic Science"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a023267"},{"key":"e_1_2_10_19_1","article-title":"Epinephrine: A Potent Modulator of Wound Healing","volume":"11","author":"Yin S.","year":"2020","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000348331"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001786"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000008884"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjac151"},{"key":"e_1_2_10_24_1","article-title":"Topical Application of Tranexamic Acid for the Reduction of Bleeding","volume":"7","author":"Ker K.","year":"2013","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2018.02.003"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003896"}],"container-title":["Wound Repair and Regeneration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/wrr.70060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T11:51:41Z","timestamp":1756209101000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/wrr.70060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/wrr.70060"],"URL":"https:\/\/doi.org\/10.1111\/wrr.70060","archive":["Portico"],"relation":{},"ISSN":["1067-1927","1524-475X"],"issn-type":[{"value":"1067-1927","type":"print"},{"value":"1524-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70060"}}