{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:45:22Z","timestamp":1791247522623,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"publisher","award":["202104070826"],"award-info":[{"award-number":["202104070826"]}],"id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The mechanism by which moist\u2010exposed burn ointment (MEBO) promotes wound healing in diabetic foot ulcers (DFUs) remains unclear. To elucidate this mechanism, we investigated the role of stromal cell\u2010derived factor\u20101 (SDF\u20101) in MEBO's ability to enhance ulcer healing and neovascularisation using a full\u2010thickness wound model in hyperglycaemic rats. On post\u2010wounding days 3, 7, and 14, the wound healing rates were significantly higher in the MEBO group compared to the model group and Vaseline group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Additionally, the MEBO group exhibited increased epidermal layer thickness and enhanced collagen fibre deposition relative to the model group and Vaseline group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Furthermore, the number of CD31\u2010positive cells and microvascular density (MVD) were significantly elevated in the MEBO group compared to the model group and Vaseline group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Flow cytometric analysis also demonstrated that the proportion of CD45\u2212, CD34+, and VEGFR2+ cells in the wound area of the MEBO\u2010treated group was significantly higher compared to the model group and Vaseline group. Expression levels of SDF\u20101, HIF\u20101\u03b1 were also markedly higher in the MEBO group compared to the model group and Vaseline group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Finally, a significant increase in double\u2010positive CXCR4 and CD31 cells was observed exclusively in the MEBO group of hyperglycaemic rats (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). These findings suggest that MEBO therapy promotes angiogenesis and accelerates wound healing through activation of the SDF\u20101\/CXCR4 axis during wound healing in diabetics.<\/jats:p>","DOI":"10.1111\/wrr.70070","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T07:30:15Z","timestamp":1753860615000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Moist\u2010Exposed Burn Ointment Promotes Angiogenesis During Full\u2010Thickness Wound Healing by Activating the <scp>SDF<\/scp>\u20101\/<scp>CXCR4<\/scp> Axis in a Hyperglycaemic Rat Model"],"prefix":"10.1111","volume":"33","author":[{"given":"Naili","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Human Anatomy School of Basic Medical Science, Binzhou Medical University  Yantai Shandong China"},{"name":"Rongxiang Xu Regenerative Medicine Research Center Binzhou Medical University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Tianjin Jizhou District People's Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Rongxiang Xu Regenerative Medicine Research Center Binzhou Medical University  Yantai Shandong China"},{"name":"School of Nursing Binzhou Medical University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxu","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy School of Basic Medical Science, Binzhou Medical University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxing","family":"Li","sequence":"additional","affiliation":[{"name":"Rongxiang Xu Regenerative Medicine Research Center Binzhou Medical 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Yantai Shandong China"},{"name":"Department of Histology and Embryology School of Basic Medical Science, Binzhou Medical University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Xu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Binzhou Medical University  Binzhou Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Blood Purification Center The Affiliated Yantai Yuhuangding Hospital of Qingdao University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Ma","sequence":"additional","affiliation":[{"name":"Rongxiang Xu Regenerative Medicine Research Center Binzhou Medical University  Yantai Shandong China"},{"name":"Department of Diagnostics The Second School of Clinical Medicine, Binzhou Medical University  Yantai Shandong 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