{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:55:28Z","timestamp":1772160928045,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["YFAA15D15AP00100"],"award-info":[{"award-number":["YFAA15D15AP00100"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["3R01HL126887\u201005S1"],"award-info":[{"award-number":["3R01HL126887\u201005S1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL126887"],"award-info":[{"award-number":["R01HL126887"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study examines immune and inflammatory responses in draining wound fluid over the course of the early stages of wound healing in patients recovering from spinal fusion surgery. The inflammatory phase of wound healing is essential for setting the stage for successful tissue repair and preventing chronic or poorly healing wounds. Scoliosis can be idiopathic or occur secondary to neuromuscular disorders, which are known to be associated with poor wound healing outcomes. We hypothesised that neuromuscular scoliosis patients would exhibit differences in inflammatory wound healing markers compared to idiopathic scoliosis patients. Comparison of the cellular and cytokine contents of draining wound fluid revealed that several inflammatory cytokines were elevated in the neuromuscular scoliosis patient group compared to idiopathic, whereas the leukocyte contents were the same between groups. This study shows that draining wound fluid is a good source of cellular and soluble biomarkers for acute wound healing and can be used to determine changes in individuals at risk for wound healing complications.<\/jats:p>","DOI":"10.1111\/wrr.70076","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T07:36:32Z","timestamp":1753860992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Analysis of Inflammatory Response in Surgical Wound Drainage Fluid in Scoliosis Surgery: A Study of Neuromuscular vs. Idiopathic Patients"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9678-4265","authenticated-orcid":false,"given":"Meredith J.","family":"Crane","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin L.","family":"McKinney","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Hasbro Children's Hospital and the Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander R. D.","family":"Jordon","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig P.","family":"Eberson","sequence":"additional","affiliation":[{"name":"Pediatric Orthopedics Division Hasbro Children's Hospital and the Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5781-9231","authenticated-orcid":false,"given":"Amanda M.","family":"Jamieson","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67700-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034509359125"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086660"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.63"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01669-w"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08741-5"},{"key":"e_1_2_10_8_1","first-page":"1701","article-title":"Role of Endothelial Selectins in Wound Repair","volume":"150","author":"Subramaniam M.","year":"1997","journal-title":"American Journal of Pathology"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64534-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63217-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600809"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.10.1339"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150713"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piy014"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.653940"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109532"},{"issue":"1","key":"e_1_2_10_17_1","article-title":"Vascular Endothelial Cdc42 Deficiency Delays Skin Wound\u2010Healing Processes by Increasing IL\u20101\u03b2 and TNF\u2010\u03b1 Expression","volume":"11","author":"Xu M.","year":"2019","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiae175"},{"key":"e_1_2_10_19_1","first-page":"1","article-title":"Adolescent Idiopathic Scoliosis","volume":"1","author":"Cheng J. 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