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Risk factors for developing a diabetic foot ulcer include age, sex, ethnicity, chronically elevated HbA\n                    <jats:sub>1c<\/jats:sub>\n                    , smoking history, cardiovascular disease, end\u2010stage renal disease, and retinopathy. Diabetic foot ulcer recurrence rates are as high as 20%, and they have vast complications, including lower\u2010extremity amputations. More recently, there has been a surge in the use of glucagon\u2010like peptide 1 receptor agonists in managing diabetes and weight loss. The use of glucagon\u2010like peptide 1 receptor agonists in treating diabetic foot ulcers in humans has not been extensively studied, but there are reports of using glucagon\u2010like peptide 1 receptor agonists in other dermatologic diseases with positive outcomes, including androgenetic alopecia and hidradenitis suppurativa. This review aims to explore the potential of using systemic glucagon\u2010like peptide 1 receptor agonists in managing diabetic foot ulcers, describing their effects on modulating wound repair, microvascular function, neuropathic symptoms, apoptosis, weight loss, oxidative stress, and inflammation. Additionally, a systematic review, following PRISMA guidelines, was conducted assessing the rate of diabetic foot complications in patients using glucagon\u2010like peptide 1 receptor agonists when compared to a control group, with the results suggesting their potentially protective role. By managing multiple facets of diabetic foot ulcer pathophysiology, the use of glucagon\u2010like peptide 1 receptor agonists may aid in their management and thus prevent recurrence.\n                  <\/jats:p>","DOI":"10.1111\/wrr.70085","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T12:00:36Z","timestamp":1756728036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Exploring the Role of\n                    <scp>GLP<\/scp>\n                    \u20101 Agents in Managing Diabetic Foot Ulcers: A Narrative and Systematic Review"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7796-325X","authenticated-orcid":false,"given":"Fiona S.","family":"Gruzmark","sequence":"first","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8207-396X","authenticated-orcid":false,"given":"Gabriela E.","family":"Beraja","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Jozic","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadar A.","family":"Lev\u2010Tov","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3654"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0043"},{"key":"e_1_2_13_4_1","unstructured":"\u201cDiabetic Foot [Internet] \u201dhttps:\/\/www.idf.org https:\/\/www.idf.org\/our\u2010activities\/care\u2010prevention\/diabetic\u2010foot.html."},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0536"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1231932"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3160"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14840"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina57101072"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18276-0"},{"key":"e_1_2_13_12_1","unstructured":"CDC \u201cNational Diabetes Statistics Report [Internet]. 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