{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:45:14Z","timestamp":1788432314572,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Wound Repair Regeneration"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dipeptidyl\u2010peptidase 4 inhibitors, DPP\u20104i, are an established antiglycaemic medication for Type 2 Diabetes. There has been a growing interest in DPP\u20104i's potential to improve wound healing and reduce fibrosis. The purpose of this study is to survey the current literature for applications of DPP\u20104i in wound healing and scars, and explore their potential outside of glycaemic control. A systematic review was performed by three independent reviewers according to PRISMA guidelines using PubMed, SCOPUS, Embase and Cochrane CENTRAL databases. Search terms were synonymous with \u2018DPP\u20104i\u2019, \u2018diabetic wounds\u2019, \u2018wound healing\u2019, \u2018scars\u2019 and \u2018skin\u2019. Studies that used DPP\u20104i in the context of wound healing, scarring, or psoriasis were included for data extraction. A total of 2139 articles were screened, resulting in 31 human, animal and in\u00a0vitro studies. Human studies showed DPP\u20104i led to faster wound closure rates, clinical improvement in psoriasis and a reduced risk of keloid formation after sternotomy. In\u00a0vitro studies reported an increase in cell migration, proliferation and angiogenesis with DPP\u20104 inhibition. DPP\u20104i was found to attenuate markers of fibrosis in multiple wound healing models and downregulate TGF\u2010\u03b2, pSmad2\/3, \u03b1\u2010SMA, Col1, Col3 and downstream effectors of the MAPK\u2010NF\u2010\u03baB pathway. This systematic review is the first to summarise and shed light on DPP\u20104i therapeutic benefits for wound healing and scarring. In multiple in\u00a0vitro, animal and human studies, DPP\u20104i have a net positive effect on cutaneous healing. Further studies are needed to reveal the specific molecular pathways through which DPP\u20104 exerts its effects, particularly in relation to wound healing, scar formation and angiogenesis.<\/jats:p>","DOI":"10.1111\/wrr.70090","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T10:29:19Z","timestamp":1757327359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["From Glucose to Gauze: A Systematic Review on the Various Wound Healing Properties of\n                    <scp>DPP<\/scp>\n                    \u20104 Inhibitors Beyond Glycaemic Control"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6533-9724","authenticated-orcid":false,"given":"Lana S.","family":"Mamoun","sequence":"first","affiliation":[{"name":"Center for Tissue Engineering, Department of Plastic Surgery University of California Irvine  Orange California USA"},{"name":"California University of Science and Medicine  Colton California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashton J.","family":"Rosenbloom","sequence":"additional","affiliation":[{"name":"Center for Tissue Engineering, Department of Plastic Surgery University of California Irvine  Orange California USA"},{"name":"The American Medical Program at Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gasbeck","sequence":"additional","affiliation":[{"name":"Center for Tissue Engineering, Department of Plastic Surgery University of California Irvine  Orange California USA"},{"name":"California Northstate University College of Medicine  Elk Grove California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Center for Tissue Engineering, Department of Plastic Surgery University of California Irvine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5705-8073","authenticated-orcid":false,"given":"Alan D.","family":"Widgerow","sequence":"additional","affiliation":[{"name":"Center for Tissue Engineering, Department of Plastic Surgery University of California Irvine  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/8145388"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14552"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2006.01178.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/368703"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311588"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0686-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2200436"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.552818"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2018.10.006"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.10.025"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S326385"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41058"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.191098"},{"issue":"12","key":"e_1_2_9_15_1","first-page":"1359","article-title":"Evaluation of Dipeptidyl Peptidase\u20104 Enzyme Inhibition by Some Commonly Used Gliptins on Cutaneous Wound Healing in Albino Rats","volume":"14","author":"Chandrashekar K. 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